Recent advances in new trifluoromethoxylation reagents
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9402-x
Abstract: The trifluoromethoxy (CF3O) group has become a novel moiety in various fields because of its unique features. However, despite the promising applications, the synthesis of CF3O-containing compounds is still a challenge due to indirect synthetical… read more here.
Keywords: trifluoromethoxylation reagents; advances new; cf3o; new trifluoromethoxylation ... See more keywords
Silver-Catalyzed Trifluoromethoxylation of Aziridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04226
Abstract: We disclose a silver-catalyzed trifluoromethoxylation of N-tosyl aziridines with trifluoromethyl arylsulfonate. The protocol is characterized by its mild conditions, simple operations, and good chemo- and regioselectivity. In addition, the trifluoromethoxylation of trisubstituted aziridines could construct… read more here.
Keywords: catalyzed trifluoromethoxylation; trifluoromethoxylation; chemistry; silver catalyzed ... See more keywords
Oxidation of difluorocarbene and subsequent trifluoromethoxylation
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DOI: 10.1038/s41467-019-13359-z
Abstract: As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process… read more here.
Keywords: difluorocarbene subsequent; oxidation difluorocarbene; oxidation; trifluoromethoxylation ... See more keywords
Nucleophilic trifluoromethoxylation of alkyl halides without silver
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DOI: 10.1038/s41467-020-14598-1
Abstract: The biological properties of molecules containing the trifluoromethoxy group have made these compounds important targets in pharmaceuticals and agrochemicals, yet their preparation is still a substantial challenge. Herein, we present a practical nucleophilic trifluoromethoxylation of… read more here.
Keywords: alkyl halides; trifluoromethoxylation; nucleophilic trifluoromethoxylation; halides without ... See more keywords
Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent
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DOI: 10.1038/s41467-020-16451-x
Abstract: Methods for direct C-H trifluoromethoxylation of arenes and heteroarenes are rare, despite the importance of trifluoromethoxylated compounds for pharmaceuticals, agrochemicals, and material sciences. Especially selective C-H trifluoromethoxylation of pyridines remains a formidable challenge. Here we… read more here.
Keywords: selective trifluoromethoxylation; trifluoromethoxylation arenes; trifluoromethoxylation; arenes heteroarenes ... See more keywords