Catalyst-free Cleavage of Amide and C-O Double Bond for the Diastereoselective Synthesis of Trifluoromethyl-Containing Dihydrooxazole Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00522
Abstract: A novel and efficient cascade method has been developed for the diastereoselective preparation of trifluoromethyl-containing dihydrooxazoles in high yields. The reaction was applicable to electron-deficient, electron-rich arenes, heteroarenes, and alkyl groups. Control experiments were conducted… read more here.
Keywords: cleavage amide; free cleavage; trifluoromethyl containing; reaction ... See more keywords
Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds
Sign Up to like & getrecommendations! Published in 2021 at "Organic chemistry frontiers"
DOI: 10.1039/d1qo00037c
Abstract: The C–F bond is the strongest single bond in organic compounds. It is the most challenging task to study the activation of the C–F bond in organic synthesis. Trifluoromethyl-containing compounds, which have three equivalent C–F… read more here.
Keywords: bond; trifluoromethyl containing; containing compounds; bond functionalization ... See more keywords
Construction of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides and derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00836c
Abstract: Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and CF3-imidoyl sulfoxonium ylides (TFISYs), are systematically summarized and discussed. The cascade annulation reactions of trifluoromethyl-containing synthons… read more here.
Keywords: heterocycles trifluoroacetimidoyl; trifluoromethyl containing; construction trifluoromethyl; trifluoroacetimidoyl chlorides ... See more keywords