Copper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters.
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DOI: 10.1021/acs.orglett.2c02027
Abstract: Herein, we describe a method to produce (Z)-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF3. This synthetic method uses inexpensive and easy-to-handle TMSCF3. It employs a commercially available CuCl catalyst… read more here.
Keywords: olefination trifluoromethylation; enol esters; trifluoromethyl enol; carboxylic acids ... See more keywords