Synthesis of 2-(Trifluoromethyl)indoles via Domino Trifluoromethylation/Cyclization of 2-Alkynylanilines.
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DOI: 10.1021/acs.orglett.8b00509
Abstract: A new method for the synthesis of 2-(trifluoromethyl)indoles using easily accessible 2-alkynylanilines and a well-established fluoroform-derived CuCF3 reagent is described. This method utilizes a domino trifluoromethylation/cyclization strategy to construct the indole cores with no ambiguity… read more here.
Keywords: domino trifluoromethylation; trifluoromethylation cyclization; trifluoromethyl indoles; synthesis trifluoromethyl ... See more keywords