Selectively Tunable Synthesis of α-Trifluoromethyl Ketones.
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DOI: 10.1021/acs.orglett.3c00725
Abstract: A cross-coupling of aldehydes and α-trifluoromethyl alkyl bromides was developed via dual nickel/photoredox catalysis system. A wide variety of substrates bearing a diverse set of functional groups were compatible to afford α-trifluoromethyl ketones under very… read more here.
Keywords: synthesis trifluoromethyl; selectively tunable; trifluoromethyl ketones; tunable synthesis ... See more keywords
Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones.
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DOI: 10.1021/acs.orglett.8b00410
Abstract: The direct oxidative addition of CF3 and H2O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various… read more here.
Keywords: trifluoromethyl ketones; multicomponent oxidative; trifluoromethylation alkynes; oxidative trifluoromethylation ... See more keywords