A facile greener synthesis, antimicrobial evaluation and molecular modelling of new 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-one derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-018-03711-1
Abstract: The synthesis of 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-ones was performed by cyclization of 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine with 2-aroylbenzoic acids in ethanol containing a catalytic amount of concentrated sulfuric acid under solid state conditions. All these synthesized compounds (8a–h) were screened for… read more here.
Keywords: phenyl naphthyridin; aryl trifluoromethyl; trifluoromethyl; trifluoromethyl phenyl ... See more keywords
Efficient biosynthesis of (S)-1-[2-(trifluoromethyl)phenyl]ethanol by a novel isolate Geotrichum silvicola ZJPH1811 in deep eutectic solvent/cyclodextrin-containing system.
Sign Up to like & getrecommendations! Published in 2021 at "Bioresource technology"
DOI: 10.1016/j.biortech.2021.124832
Abstract: This study aimed to develop a biotransformation process for the production of (S)-1-[2-(trifluoromethyl)phenyl]ethanol, a key chiral intermediate of Plk1 inhibitor, and increase its productivity through medium engineering strategy. A fungus isolate Geotrichum silvicola ZJPH1811 was… read more here.
Keywords: trifluoromethyl phenyl; system; trifluoromethyl; phenyl ethanol ... See more keywords
Investigation of spectroscopic, reactive, transport and docking properties of 1-(3,4-dichlorophenyl)-3-[3-(trifluoromethyl)phenyl]thiourea (ANF-6): Combined experimental and computational study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.01.016
Abstract: Abstract The wavenumbers, molecular structure, molecular electrostatic potential, nonlinear optical properties and natural bond orbital analysis of a thiourea derivative, 1-(3,4-dichlorophenyl)-3-[3-(trifluoromethyl)phenyl]thiourea (ANF-6) were reported. For the title molecule, HOMO is all over the molecule except… read more here.
Keywords: thiourea; study; phenyl thiourea; dichlorophenyl trifluoromethyl ... See more keywords
Structure, spectroscopic analyses (FT-IR and NMR), vibrational study, chemical reactivity and molecular docking study on 3,3'-((4-(trifluoromethyl)phenyl)methylene)bis(2-hydroxynaphthalene-1,4-dione), a promising anticancerous bis-lawsone derivative
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.09.095
Abstract: Abstract Lawsone (2-hydroxy-1,4-naphthoquinone)has been evaluated to possess a wide range of biological and pharmacological activities. The interesting structural pattern of lawsone coupled with its so-called multifaceted pharmacological potential have made this scaffolds useful in certain… read more here.
Keywords: phenyl methylene; lawsone; study; bis ... See more keywords
Visible-light-promoted S-trifluoromethylation of thiophenols with trifluoromethyl phenyl sulfone.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03921d
Abstract: Trifluoromethyl phenyl sulfone is traditionally a nucleophilic trifluoromethylating agent. Herein, we report the first example of the use of trifluoromethyl phenyl sulfone as a trifluoromethyl radical precursor. Arylthiolate anions can form electron donor-acceptor (EDA) complexes… read more here.
Keywords: trifluoromethyl phenyl; trifluoromethylation thiophenols; phenyl sulfone; visible light ... See more keywords
Transmembrane fluoride anion transport by meso-3,5-bis(trifluoromethyl)phenyl picket calix[4]pyrrole.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc02032k
Abstract: Meso-3,5-bis(trifluoromethyl)phenyl picket calix[4]pyrrole 1 displays excellent fluoride anion transport activity across artificial lipid bilayers showing EC50 = 2.15 μM (at 450 s in EYPC vesicle) with high fluoride over chloride ion selectivity. The high fluoride… read more here.
Keywords: meso bis; bis trifluoromethyl; trifluoromethyl phenyl; picket calix ... See more keywords
Green synthesis of diethyl((2-iodo-4-(trifluoromethyl)phenyl)amino)(aryl)methyl)phosphonates as potent α-glucosidase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1709208
Abstract: Abstract Novel diethyl((2-iodo-4-(trifluoromethyl)phenyl)amino)(aryl)methyl)phosphonates (4a-j) were synthesized via a simple and efficient one pot by three-component condensation reaction (Kabachnik-Fields reaction) of 2-iodo-4-trifluoromethyl aniline, aromatic aldehydes and diethyl phosphite in presence of anatase TiO2 nanoparticles as catalyst… read more here.
Keywords: diethyl iodo; iodo trifluoromethyl; phenyl amino; iodo ... See more keywords
N-[2-(Trifluoromethyl)phenyl]maleamic acid: crystal structure and Hirshfeld surface analysis
Sign Up to like & getrecommendations! Published in 2019 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989019006509
Abstract: The –COOH group of the title compound adopts a syn conformation (O= C—O—H = 0°) unlike the anti conformation observed in related maleamic acids. This is correlated with the formation of carboxylic acid inversion dimers… read more here.
Keywords: acid crystal; phenyl maleamic; structure hirshfeld; trifluoromethyl phenyl ... See more keywords
Crystal structures of N-[4-(trifluoromethyl)phenyl]benzamide and N-(4-methoxyphenyl)benzamide at 173 K: a study of the energetics of conformational changes due to crystal packing
Sign Up to like & getrecommendations! Published in 2022 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989022000950
Abstract: The conformations of two aryl amides have been determined experimentally in crystal structures using X-ray data and calculated with DFT methods for the isolated molecules. Geometrical comparisons are made along with energy analyses of the… read more here.
Keywords: phenyl benzamide; trifluoromethyl phenyl; structures trifluoromethyl; crystal structures ... See more keywords
Crystal Structures of 2-Chloro-3-((3-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione and 2-Chloro-3-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione
Sign Up to like & getrecommendations! Published in 2019 at "Crystallography Reports"
DOI: 10.1134/s1063774519070289
Abstract: 2-Chloro-3-((3-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione (1) and 2-chloro-3-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione (2) were obtained according to the method reported previously. The crystal structures of both compounds were determined by the single crystal X-ray diffraction method. The molecules are non-planar: torsion angles around… read more here.
Keywords: naphthalene dione; chloro trifluoromethyl; amino naphthalene; phenyl amino ... See more keywords
Synthesis of Novel Pyridine Bearing Biologically Active Imidiazolyl, Pyrazolyl, Oxa/thiadiazolyl and Urea Derivatives as Promising Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2020 at "Current organic synthesis"
DOI: 10.2174/1570179417666191223163225
Abstract: BACKGROUND A novel series of pyridine containing 1,3,4-oxa/thiadiazol derivatives 4a,b, pyrazole derivatives 5-7, thiazole derivatives 9a,b and 17a-c, urea derivatives 12a-c, imidiazole derivative 16, imidazo[1,2-a]pyridine derivatives 18a, b, tetrazole 19, pyrane 20 and pyridine derivatives… read more here.
Keywords: trifluoromethyl phenyl; trifluoromethyl trifluoromethyl; pyridine; phenyl amino ... See more keywords