Sequential one-pot three-step synthesis of polysubstituted 4-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazole systems
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DOI: 10.1039/c7ra07960e
Abstract: This work reports a successful one-pot three-step protocol for the synthesis of a new series of 15 examples of polysubstituted 4-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazoles, in which sequential Sonogashira cross-coupling, desilylation, and a copper(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) with… read more here.
Keywords: three step; trifluoromethyl pyrazol; polysubstituted trifluoromethyl; one pot ... See more keywords
Efficient Synthesis and Antimicrobial Activities of Long Alkyl Chain Trifluoromethyl1H-pyrazol-1-(thio)carboxamides and Trifluoromethyl-1H-pyrazol-1-yl-thiazoles
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DOI: 10.21577/0103-5053.20200241
Abstract: The synthesis of 3-alkyl-5-trifluoromethyl-1Hpyrazole-1-carboxamides, 3-alkyl5-trifluoromethyl-1H-pyrazole-1-thiocarboxamides, and 2-(3-alkyl-5-trifluoromethyl-1H-pyrazol1-yl)-thiazoles derivatives are reported. [3 + 2] cyclocondensations for a series of long alkyl chain 1,1,1-trifluoro-4-methoxyalk-3-en-2-ones and semicarbazide or thiosemicarbazide were carried out in ethanol, an eco-friendly medium. The… read more here.
Keywords: long alkyl; pyrazol thiazoles; alkyl chain; trifluoromethyl pyrazol ... See more keywords