Copper-Mediated Domino Cyclization/Trifluoromethylation/Deprotection with TMSCF3: Synthesis of 4-(Trifluoromethyl)pyrazoles.
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DOI: 10.1021/acs.orglett.6b03822
Abstract: A copper-mediated synthesis of 4-(trifluoromethyl)pyrazoles is described. In one step from readily accessible α,β-alkynic tosylhydrazones, a remarkable domino sequence of cyclization, trifluoromethylation, and detosylation takes place to furnish the 4-CF3 N-H pyrazole cores with good… read more here.
Keywords: copper mediated; cyclization trifluoromethylation; trifluoromethyl pyrazoles; synthesis trifluoromethyl ... See more keywords