Zinc-Enabled Annulation of Trifluorodiazoethane with 2H-Azirines to Construct Trifluoromethyl Pyrazolines, Pyrazoles, and Pyridazines.
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DOI: 10.1021/acs.orglett.1c02139
Abstract: A diethylzinc-promoted unconventional annulation reaction of 2,2,2-trifluorodiazoethane with 2H-azirines is described. This transformation involves two [3 + 2] cycloaddition steps and one dinitrogen extrusion process in one pot, thus giving a broad array of 3-trifluoromethyl… read more here.
Keywords: annulation; trifluoromethyl pyrazolines; trifluoromethyl; zinc enabled ... See more keywords