Synthesis of Trifluoromethyl‐Substituted Tetrazoles via KI/TBHP‐Mediated Oxidative Annulation of Trifluoroacetimidohydrazides and Nitromethane
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DOI: 10.1002/ajoc.70204
Abstract: A metal‐free strategy for the preparation of trifluoromethyl‐substituted tetrazoles via KI/TBHP‐mediated oxidative annulation of readily available trifluoroacetimidohydrazides (TFAIHs) and nitromethane has been disclosed. In this transformation, CH3NO2 is applied as both the inexpensive nitrogen synthon… read more here.
Keywords: mediated oxidative; tetrazoles via; substituted tetrazoles; via tbhp ... See more keywords
Synthesis of ethyl α-nitro-β-trifluoromethyl acrylate and β-trifluoromethyl-substituted tryptophan analogs and their plant growth regulating activity
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DOI: 10.1007/s11172-017-1863-z
Abstract: Ethyl α-nitro-β-trifluoromethyl acrylate was synthesized by nucleophile-catalyzed reaction of ethyl nitroacetate with excess trifluoroacetaldehyde methyl hemiacetal and subsequent dehydration of the intermediate alcohol with P2O5. The synthesized nitro olefin regioselectively reacts with the substituted indoles… read more here.
Keywords: ethyl nitro; trifluoromethyl; substituted tryptophan; nitro trifluoromethyl ... See more keywords
Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions
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DOI: 10.1039/c6qo00723f
Abstract: Unprecedented asymmetric exo′-selective [3 + 2] cycloaddition reactions of CF3-containing isatin-derived azomethine ylides with methyleneindolinones have been disclosed. Under bifunctional organocatalysis by cinchona-derived squaramide catalysts, a series of potential biologically important trifluoromethylated 3,3′-pyrrolidinyl-dispirooxindoles were efficiently… read more here.
Keywords: pyrrolidinyl dispirooxindoles; cycloaddition reactions; synthesis trifluoromethyl; asymmetric synthesis ... See more keywords
Electron-deficient trifluoromethyl-substituted sub-components affect the properties of M4L4 tetrahedral cages.
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DOI: 10.1039/c7dt02182h
Abstract: Two supramolecular tetrahedral cages based on a new electron-deficient trifluoromethyl-substituted pyridylimine ligand are synthesised by sub-component self-assembly. Their structures are characterised by NMR und UV-Vis spectroscopy, high-resolution mass spectrometry and single crystal X-ray diffraction. The… read more here.
Keywords: tetrahedral cages; electron deficient; substituted sub; deficient trifluoromethyl ... See more keywords