A novel access to 4-trifluoromethyl-1,3-thiazole derivatives via an intermediate thiocarbonyl ylide
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DOI: 10.1016/j.jfluchem.2019.02.003
Abstract: Abstract A Lewis acid catalyzed reaction of trifluoroacetyldiazomethane (CF3COCHN2) with thiourea occurs in boiling THF solution in the presence of BF3·OEt2 yielding 2-amino-4-trifluoromethyl-1,3-thiazole in a fair yield. Analogous reactions with aromatic thioamides, performed in the… read more here.
Keywords: trifluoromethyl thiazole; thiazole derivatives; access trifluoromethyl; derivatives via ... See more keywords