Defluoroalkylation of Trifluoromethylarenes with Hydrazones: Rapid Access to Benzylic Difluoroarylethylamines
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DOI: 10.1021/acs.orglett.3c00126
Abstract: Here, we report an efficient and modular approach toward the formation of difluorinated arylethylamines from simple aldehyde-derived N,N-dialkylhydrazones and trifluoromethylarenes (CF3-arenes). This method relies on selective C–F bond cleavage via reduction of the CF3-arene. We… read more here.
Keywords: defluoroalkylation trifluoromethylarenes; hydrazones rapid; trifluoromethylarenes hydrazones; rapid access ... See more keywords