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Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01513
Abstract: We developed a novel asymmetric Friedel-Crafts alkylation/transamidation tandem reaction for the enantio- and diastereoselective synthesis of pyrazolo[3,4-b]pyridin-6-ones bearing a -CF3 unit via synergistic chiral phosphoric acid and MgSO4 catalysis. This [3 + 3] annulation protocol…
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Keywords:
trifluoromethylated pyrazolo;
chiral phosphoric;
acid mgso4;
pyridin ones ... See more keywords