Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones.
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DOI: 10.1021/acs.orglett.8b00410
Abstract: The direct oxidative addition of CF3 and H2O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various… read more here.
Keywords: trifluoromethyl ketones; multicomponent oxidative; trifluoromethylation alkynes; oxidative trifluoromethylation ... See more keywords
Copper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes
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DOI: 10.1055/s-0039-1690187
Abstract: The copper-catalyzed radical bis(trifluoromethylation) of alkynes and 1,3-enynes is described. With Cu(CH3CN)4BF4 as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF3)2at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes in good yields… read more here.
Keywords: radical bis; bis trifluoromethylation; bis; catalyzed radical ... See more keywords