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   Articles with "trifluoromethylation cyclization" as a keyword



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Catalyst-free, direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF3 source

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recommendations! Published in 2021 at "Chinese Chemical Letters"

DOI: 10.1016/j.cclet.2021.06.008

Abstract: Abstract A new electrochemical strategy for trifluoromethylation/cyclization using TfNHNHBoc as a CF3 source was established. This approach was realized by the direct electrolysis of TfNHNHBoc under external oxidant-free and catalyst-free conditions, and afforded various trifluoromethylated… read more here.

Keywords: cf3 source; tfnhnhboc cf3; trifluoromethylation cyclization; catalyst free ... See more keywords
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Synthesis of Trifluoromethylated Naphthoquinones via Copper-Catalyzed Cascade Trifluoromethylation/Cyclization of 2-(3-Arylpropioloyl)benzaldehydes.

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recommendations! Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b00095

Abstract: A novel copper-catalyzed cascade trifluoromethylation/cyclization of 2-(3-arylpropioloyl)benzaldehydes is described, allowing a direct access to structurally diverse trifluoromethylated naphthoquinones under mild reaction conditions. It represents the first trans-acyltrifluoromethylation of internal alkynes. read more here.

Keywords: cyclization arylpropioloyl; arylpropioloyl benzaldehydes; trifluoromethylation cyclization; cascade trifluoromethylation ... See more keywords
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Synthesis of 2-(Trifluoromethyl)indoles via Domino Trifluoromethylation/Cyclization of 2-Alkynylanilines.

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recommendations! Published in 2018 at "Organic letters"

DOI: 10.1021/acs.orglett.8b00509

Abstract: A new method for the synthesis of 2-(trifluoromethyl)indoles using easily accessible 2-alkynylanilines and a well-established fluoroform-derived CuCF3 reagent is described. This method utilizes a domino trifluoromethylation/cyclization strategy to construct the indole cores with no ambiguity… read more here.

Keywords: domino trifluoromethylation; trifluoromethylation cyclization; trifluoromethyl indoles; synthesis trifluoromethyl ... See more keywords