3-Position-Selective C-H Trifluoromethylation of Pyridine Rings Based on Nucleophilic Activation.
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DOI: 10.1021/acs.orglett.2c03327
Abstract: The first example of the 3-position-selective C(sp2)-H trifluoromethylation of pyridine rings was established. 3-Position-selective trifluoromethylation was achieved by the nucleophilic activation of pyridine and quinoline derivatives through hydrosilylation and successive electrophilic trifluoromethylation of the enamine… read more here.
Keywords: pyridine rings; position selective; trifluoromethylation pyridine; trifluoromethylation ... See more keywords