Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy.
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DOI: 10.1016/j.bbrc.2022.04.063
Abstract: Trifluridine, a key component of trifluridine/tipiracil, is a potential anti-cancer drug that can act effectively on refractory metastatic colorectal cancer. Chemotherapy is important for cancer treatment, but its adverse effects limit its use. Long-term side-effects… read more here.
Keywords: autophagy; trifluridine induces; senescence; mtor ... See more keywords