Panitumumab Plus Trifluridine-Tipiracil as Anti-Epidermal Growth Factor Receptor Rechallenge Therapy for Refractory RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2023.0655
Abstract: Importance Current third-line therapies for patients with metastatic colorectal cancer (MCRC) have limited efficacy. Rechallenge with epidermal growth factor receptor (EGFR) inhibitors for RAS wild-type (WT) MCRC may be valuable for these patients. Objective To… read more here.
Keywords: refractory ras; therapy; panitumumab plus; plus trifluridine ... See more keywords
Feasibility and effectiveness of trifluridine/tipiracil in metastatic colorectal cancer: real-life data from The Netherlands
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DOI: 10.1007/s10147-017-1220-0
Abstract: BackgroundThe RECOURSE trial showed clinical efficacy for trifluridine/tipiracil for refractory metastatic colorectal cancer patients. We assessed the feasibility and effectiveness of trifluridine/tipiracil in daily clinical practice in The Netherlands.MethodsMedical records of patients from 17 centers… read more here.
Keywords: metastatic colorectal; trifluridine tipiracil; tipiracil; feasibility effectiveness ... See more keywords
An exploration of trifluridine/tipiracil in combination with irinotecan in patients with pretreated advanced gastric cancer
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DOI: 10.1007/s10637-022-01223-9
Abstract: Background. Trifluridine/tipiracil (FTD/TPI) and irinotecan are treatment options for heavily pretreated patients with advanced gastric cancer, but their efficacies are limited. We investigated the combination of FTD/TPI and irinotecan for such patients. Methods. Patients who… read more here.
Keywords: level; trifluridine tipiracil; advanced gastric; gastric cancer ... See more keywords
The OCT2/MATE1 Interaction Between Trifluridine, Metformin and Cimetidine: A Crossover Pharmacokinetic Study
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DOI: 10.1007/s40262-024-01390-3
Abstract: Trifluridine/tipiracil, registered for the treatment of patients with metastatic gastric and colorectal cancer, is a substrate and inhibitor for the organic cation transporter 2 (OCT2) and the multidrug and toxin extrusion protein 1 (MATE1), which… read more here.
Keywords: cimetidine; trifluridine; oct2 mate1; trifluridine tipiracil ... See more keywords
Impact of renal impairment on early development of severe neutropenia with trifluridine/tipiracil treatment for metastatic colorectal cancer
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DOI: 10.1038/s41598-024-78741-4
Abstract: Trifluridine/tipiracil (FTD/TPI) with or without bevacizumab is an effective treatment for metastatic colorectal cancer (mCRC). As this agent is mainly excreted via the kidney, we aimed to evaluate the impact of renal impairment (RI) on… read more here.
Keywords: treatment metastatic; treatment; ftd tpi; trifluridine tipiracil ... See more keywords
Plain language summary of SUNLIGHT: trifluridine/tipiracil and bevacizumab for refractory metastatic colorectal cancer
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DOI: 10.1080/14796694.2024.2366100
Abstract: Summary What is this summary about? This is a summary describing the results from a phase 3 clinical trial called SUNLIGHT. The study looked at treatment with orally administered trifluridine/tipiracil plus intravenously administered bevacizumab in… read more here.
Keywords: cancer; treatment; tipiracil; trifluridine tipiracil ... See more keywords
Post-marketing surveillance study of trifluridine/tipiracil in patients with metastatic colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyaa243
Abstract: BACKGROUND The novel oral nucleoside antineoplastic agent trifluridine/tipiracil was approved for metastatic colorectal cancer in Japan in March 2014. In this post-marketing surveillance study, we investigated the safety and efficacy of trifluridine/tipiracil in a real-world… read more here.
Keywords: metastatic colorectal; trifluridine tipiracil; tipiracil; colorectal cancer ... See more keywords
Integrated safety summary for trifluridine/tipiracil (TAS-102)
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DOI: 10.1097/cad.0000000000000554
Abstract: Trifluridine/tipiracil, an oral treatment combining trifluridine (an antineoplastic thymidine-based nucleoside analog) and tipiracil hydrochloride (a thymidine phosphorylase inhibitor), led to significant improvement in overall survival in metastatic colorectal cancer (mCRC) patients refractory to standard therapy… read more here.
Keywords: trifluridine tipiracil; tipiracil; safety; group ... See more keywords
Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real‐World Evidence From Regorafenib and Trifluridine/Tipiracil Use
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DOI: 10.1111/jgh.16909
Abstract: This study aims to evaluate the real‐world effectiveness and safety of sequential treatment with regorafenib and trifluridine/tipiracil (FTD‐TPI) in patients with metastatic colorectal cancer (mCRC) in Taiwan. read more here.
Keywords: colorectal cancer; sequential treatment; metastatic colorectal; regorafenib trifluridine ... See more keywords
Safety, efficacy and patient-reported outcomes with trifluridine/tipiracil in pretreated metastatic colorectal cancer: results of the PRECONNECT study
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DOI: 10.1136/esmoopen-2020-000698
Abstract: Background In RECOURSE (, trifluridine/tipiracil significantly improved overall survival and progression-free survival (PFS) versus placebo in patients with pretreated metastatic colorectal cancer (mCRC). PRECONNECT was designed to further characterise safety and clinical use of trifluridine/tipiracil.… read more here.
Keywords: metastatic colorectal; trifluridine tipiracil; tipiracil; safety ... See more keywords
[18F]fluorothymidine PET Informs the Synergistic Efficacy of Capecitabine and Trifluridine/Tipiracil in Colon Cancer.
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DOI: 10.1158/0008-5472.can-17-1406
Abstract: In cancer therapy, enhanced thymidine uptake by the salvage pathway can bypass dTMP depletion, thereby conferring resistance to thymidylate synthase inhibition. We investigated whether sequential combination therapy of capecitabine and trifluridine/tipiracil (TAS-102) could synergistically enhance… read more here.
Keywords: trifluridine tipiracil; tipiracil; capecitabine; cancer ... See more keywords