Optogenetic activation of dopamine receptor D1 and D2 neurons in anterior cingulate cortex differentially modulates trigeminal neuropathic pain
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02020-2
Abstract: Anterior cingulate cortex (ACC) is a critical brain center for chronic pain processing. Dopamine signaling in the brain has been demonstrated to contribute to descending pain modulation. However, the role of ACC dopamine receptors in… read more here.
Keywords: optogenetic activation; dopamine; neuropathic pain; trigeminal neuropathic ... See more keywords
Upregulation of Cdh1 in the trigeminal spinal subnucleus caudalis attenuates trigeminal neuropathic pain via inhibiting GABAergic neuronal apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104613
Abstract: Trigeminal neuropathic pain (TNP) remains a tremendous clinical challenge due to its elusive mechanisms. Previous studies showed that peripheral nerve injury facilitated a selective GABAergic neuronal apoptosis in the superficial dorsal horn and contributed to… read more here.
Keywords: apoptosis; neuronal apoptosis; neuropathic pain; trigeminal neuropathic ... See more keywords
Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.05.034
Abstract: Trigeminal neuropathic pain (TGN) is an attacking, abrupt, electric-shock headache involving abnormal cortical activity. The neural mechanism underlying TGN remains elusive. In this study, we explored the role of microglia in the primary somatosensory barrel… read more here.
Keywords: primary somatosensory; tgn; microglia primary; neuropathic pain ... See more keywords
Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway–produced analgesic effect in a trigeminal neuropathic pain mouse model
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DOI: 10.1097/j.pain.0000000000001414
Abstract: Abstract Neuropathic pain represents a challenge to clinicians because it is resistant to commonly prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a descending dopaminergic pathway–mediated modulation of trigeminal neuropathic pain. We… read more here.
Keywords: dopaminergic pathway; descending dopaminergic; neuropathic pain; spinal trigeminal ... See more keywords
Ceftriaxone Relieves Trigeminal Neuropathic Pain Through Suppression of Spatiotemporal Synaptic Plasticity via Restoration of Glutamate Transporter 1 in the Medullary Dorsal Horn
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00199
Abstract: Using a rat model of trigeminal neuropathic pain (TNP) produced by chronic compression of the infraorbital nerve (CCI-ION), we investigated the analgesic effect and the underlying mechanisms of ceftriaxone (Cef), a β-lactam antibiotic, that is… read more here.
Keywords: dorsal horn; medullary dorsal; restoration; trigeminal neuropathic ... See more keywords
Pathophysiology of Post-Traumatic Trigeminal Neuropathic Pain
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DOI: 10.3390/biom12121753
Abstract: Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from this condition have a significantly reduced quality of life. The currently available management modalities are associated with limited success. This… read more here.
Keywords: pathophysiology; neuropathic pain; pain; traumatic trigeminal ... See more keywords
Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model
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DOI: 10.3390/ijms19113320
Abstract: Transient receptor potential ankyrin type-1 (TRPA1) channels are known to actively participate in different pain conditions, including trigeminal neuropathic pain, whose clinical treatment is still unsatisfactory. The aim of this study was to evaluate the… read more here.
Keywords: treatment; transient receptor; neuropathic pain; type ... See more keywords
Interventional Management of Refractory Trigeminal Neuropathic Pain: A Prospective Audit of a Novel Management Pathway in 70 Patients.
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DOI: 10.36076/ppj.2020/23/e525
Abstract: BACKGROUND Trigeminal neuropathic pain (TNP) can present as a constant, unremitting unilateral facial pain. Current management is based on expert recommendation that includes pharmacologic agents and psychological therapy. However, treatment success with pharmacologic management is… read more here.
Keywords: management; pain; treatment; audit novel ... See more keywords