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Trigger‐dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis

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0 Published in 2020 at "European Journal of Immunology"

DOI: 10.1002/eji.201948123

Abstract: Familial hemophagocytic lymphohistiocytosis (FHL) is a hyperinflammatory syndrome affecting patients with genetic cytotoxicity defects. Perforin‐deficient (PKO) mice recapitulate the full clinical picture of FHL after infection with lymphocytic choriomeningitis virus (LCMV). Hyperactivated CD8+ T cells… read more here.

Keywords: dependent differences; hemophagocytic lymphohistiocytosis; infection; trigger dependent ... See more keywords