Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3.
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DOI: 10.1039/c7cc06802f
Abstract: Cysteine and glutathione are able to reduce Cu(ii) coordinated to the peptide amyloidβ4-16, and shuttle the resulting Cu(i) to partially replace Zn(ii) in the protein Zn7-metallothionein-3. The released Zn(ii) in turn binds to amyloid-β4-16. Thus… read more here.
Keywords: zn7 metallothionein; cysteine glutathione; trigger swap; glutathione ... See more keywords