Strictosidine Synthase Triggered Enantioselective Synthesis of N-Substituted (S)-3,14,18,19-Tetrahydroangustines as Novel Topoisomerase I Inhibitors.
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DOI: 10.1021/acschembio.7b00740
Abstract: Monoterpenoid indole alkaloids (MIAs) comprise an important class of molecules for drug discovery, and they have variant carbon skeletons with prominent bioactivities. For instance, in spite of limitations to their use, camptothecins are the only… read more here.
Keywords: synthase triggered; top1; triggered enantioselective; strictosidine synthase ... See more keywords