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Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

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0 Published in 2018 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.13632

Abstract: Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR… read more here.

Keywords: microenvironment; triggered mtor; pim kinases; migration ... See more keywords