Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24252
Abstract: The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. TREM2 can be activated by antibodies targeting the… read more here.
Keywords: trem2; receptor expressed; triggering receptor; myeloid cells ... See more keywords
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.09.034
Abstract: Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regulates release of cytokine, contributes… read more here.
Keywords: expressed myeloid; histidine 157; myeloid cells; receptor expressed ... See more keywords
Soluble Triggering Receptor Expressed on Myeloid Cells 1 in lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28971-0
Abstract: Soluble Triggering Receptor Expressed on Myeloid Cells 1 (sTREM-1) can be found in the sera of patients with infectious, autoimmune and malignant diseases. The primary objective of this study was to investigate the prognostic significance… read more here.
Keywords: soluble triggering; strem; lung cancer; cancer ... See more keywords
Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1486823
Abstract: ABSTRACT Introduction: There are currently no effective therapeutics for Alzheimer disease (AD). Clinical trials targeting amyloid beta thus far have shown very little benefit and only in the earliest stages of disease. These limitations have… read more here.
Keywords: expressed myeloid; alzheimer disease; myeloid cells; receptor expressed ... See more keywords
Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2017.1392855
Abstract: ABSTRACT Introduction: Periodontal diseases are polymicrobial inflammatory disorders of the tissue, ligament, and bone structures supporting teeth. Periodontitis (inflammation with corresponding loss of attachment) affects 40–50% of adults. Recently, members of the Triggering Receptor on… read more here.
Keywords: expressed myeloid; inflammation; receptor expressed; triggering receptor ... See more keywords
Upstream stimulatory factor 2 (USF2) induced upregulation of triggering receptor expressed on myeloid cells 1 (TREM1) promotes endometritis by regulating toll-like receptor (TLR) 2/4-nuclear factor-kappaB (NF-κB) signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2030619
Abstract: ABSTRACT Triggering receptor expressed on myeloid cells 1 (TREM1) participates in the development of endometritis. This study aims at identifying the effects and interaction of TREM1 and upstream stimulatory factor 2 (USF2) in endometritis by… read more here.
Keywords: signaling pathway; receptor expressed; triggering receptor; factor ... See more keywords
Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvy018
Abstract: Aims TREM-1 (Triggering Receptor Expressed on Myeloid cells-1) is an immunoreceptor expressed on neutrophils and monocytes/macrophages whose role is to amplify the inflammatory response driven by Toll-Like Receptors engagement. The pharmacological inhibition of TREM-1 confers… read more here.
Keywords: septic shock; receptor expressed; triggering receptor; deletion ... See more keywords
Triggering Receptor Expressed on Myeloid Cells 2, a Novel Regulator of Immunocyte Phenotypes, Confers Neuroprotection by Relieving Neuroinflammation
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001628
Abstract: Background: Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. Methods: Mice were subjected to middle cerebral artery… read more here.
Keywords: expressed myeloid; immunocyte phenotypes; myeloid cells; receptor expressed ... See more keywords
The triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway in diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000002167
Abstract: ABSTRACT Triggering receptor expressed on myeloid cells 2 (TREM2) is a membrane receptor on myeloid cells and plays an important role in the body's immune defense. Recently, TREM2 has received extensive attention from researchers, and… read more here.
Keywords: receptor expressed; cells apolipoprotein; triggering receptor; myeloid cells ... See more keywords
Role of triggering receptor expressed on myeloid cells 2 in neuroinflammation and neurodegeneration of the central nervous system
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DOI: 10.1111/cen3.12479
Abstract: Triggering receptor expressed on myeloid cells 2 (TREM2) is a member of the TREM family of innate immune receptors. It is expressed on the cell membrane of myeloid lineage cells including osteoclasts and microglia. Since… read more here.
Keywords: expressed myeloid; myeloid cells; receptor expressed; role ... See more keywords
Discrepancies in reference values of soluble Triggering Receptor Expressed on Myelocytes 1 (sTREM‐1) question the reliability of related studies
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.12849
Abstract: Soluble Triggering Receptor Expressed on Myelocytes 1 (sTREM-1) is a promising innate immunity biomarker that may be able to differentiate infectious from aseptic (non-infectious) systemic inflammation. Ambiguous results on its discriminative value have been reported… read more here.
Keywords: soluble triggering; receptor expressed; expressed myelocytes; myelocytes strem ... See more keywords