An eight-compound mixture but not corresponding concentrations of individual chemicals induces triglyceride accumulation in human liver cells.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152857
Abstract: In real life, organisms are exposed to complex mixtures of chemicals at low concentration levels, whereas research on toxicological effects is mostly focused on single compounds at comparably high doses. Mixture effects deviating from the… read more here.
Keywords: accumulation; triglyceride accumulation; compound; liver cells ... See more keywords
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids[S]
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m074427
Abstract: Lipid accumulation is a pathological feature of every type of kidney injury. Despite this striking histological feature, physiological accumulation of lipids in the kidney is poorly understood. We studied whether the accumulation of lipids in… read more here.
Keywords: kidney triglyceride; accumulation; triglyceride accumulation; fasted mouse ... See more keywords
Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13010112
Abstract: The metabolic basis of Parkinson’s disease pathology is poorly understood. However, the involvement of mitochondrial and endoplasmic reticulum stress in dopamine neurons in disease aetiology is well established. We looked at the effect of rotenone-… read more here.
Keywords: mitochondrial endoplasmic; endoplasmic reticulum; stress; parkinson disease ... See more keywords
LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023091
Abstract: Long noncoding RNAs (lncRNAs) have been widely proven to be involved in liver lipid homeostasis. Herein, we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in HepG2 cells. Knockdown… read more here.
Keywords: rapamycin treatment; triglyceride accumulation; vldl; hk1 ... See more keywords