Impact of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab on the postprandial responses of triglyceride-rich lipoproteins in type II diabetic subjects.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2019.12.003
Abstract: BACKGROUND Monoclonal antibodies to proprotein convertase subtilisin/kexin type 9 (PCSK9) significantly lower the levels of low-density lipoprotein and very-low-density lipoproteins (VLDL), but their effect on postprandial lipoprotein metabolism in dyslipidemic subjects is unclear. OBJECTIVE This… read more here.
Keywords: triglyceride rich; proprotein convertase; cholesterol; postprandial responses ... See more keywords
Proteinuria converts hepatic heparan sulfate to an effective proprotein convertase subtilisin kexin type 9 enzyme binding partner.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.01.023
Abstract: Hepatic uptake of triglyceride-rich remnant lipoproteins is mediated by the low-density lipoprotein receptor, a low-density lipoprotein receptor related protein and the heparan sulfate proteoglycan, syndecan-1. Heparan sulfate proteoglycan also mediates low-density lipoprotein receptor degradation by… read more here.
Keywords: rich remnant; sulfate; triglyceride rich; heparan sulfate ... See more keywords
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-022-00676-y
Abstract: Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only revealed a relationship between plasma triglyceride levels and the risk of atherosclerotic… read more here.
Keywords: plasma triglyceride; triglyceride rich; disease; triglyceride ... See more keywords
A Meal Rich in Palm Oil or Butter Modifies the Sphingolipid Profile of Postprandial Triglyceride-Rich Lipoproteins From Type 2 Diabetic Patients
Sign Up to like & getrecommendations! Published in 2022 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzac057.016
Abstract: Abstract Objectives Elevated concentrations of triglyceride-rich lipoproteins (TGRL) in the fasting and postprandial states are a risk factor for cardiovascular events in type 2 diabetes (T2D). Dyslipidemia in T2D is associated with modifications in the… read more here.
Keywords: triglyceride rich; palm; tgrl; rich lipoproteins ... See more keywords
Kinetics of plasma triglycerides in abdominal obesity
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DOI: 10.1097/mol.0000000000000375
Abstract: Purpose of review Abdominal obesity is associated with a number of important metabolic abnormalities including liver steatosis, insulin resistance and an atherogenic lipoprotein profile (termed dyslipidemia). The purpose of this review is to highlight recent… read more here.
Keywords: triglycerides abdominal; triglyceride rich; plasma triglycerides; kinetics plasma ... See more keywords
Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000875
Abstract: Purpose of review Despite indisputable role of LDL-C lowering, a considerable residual risk for atherosclerotic cardiovascular disease (ASCVD) persists. The precise mechanism(s) underlying this phenomenon remain unclear. Triglyceride-rich lipoproteins (TRL) appear to be one of… read more here.
Keywords: triglyceride rich; cardiovascular disease; rich lipoproteins; atherosclerotic cardiovascular ... See more keywords
Correlation of Triglyceride-Rich Lipoprotein Cholesterol and Diabetes Mellitus in Stroke Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/7506767
Abstract: Background Previous studies have revealed that triglyceride-rich lipoprotein cholesterol (TRL-c) is closely related to diabetes mellitus (DM) in hypertensive patients. However, this relationship in stroke patients has not been reported. The aims of this study… read more here.
Keywords: rich lipoprotein; triglyceride rich; lipoprotein cholesterol; lipoprotein ... See more keywords
The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ilr120000783
Abstract: REAGENTS: Mixed fatty acids (U-D, 96–98%) (Cambridge Isotope Laboratories). The lipolytic processing of triglyceride-rich lipoproteins (TRLs) by lipoprotein lipase has been studied at the biochemical level for >60 years (1, 2), but until recently it… read more here.
Keywords: processing triglyceride; triglyceride rich; rich lipoproteins; secondary ions ... See more keywords
Effect of functional sympathetic nervous system impairment of the liver and abdominal visceral adipose tissue on circulating triglyceride-rich lipoproteins
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DOI: 10.1371/journal.pone.0173934
Abstract: Background Interruption of sympathetic innervation to the liver and visceral adipose tissue (VAT) in animal models has been reported to reduce VAT lipolysis and hepatic secretion of very low density lipoprotein (VLDL) and concentrations of… read more here.
Keywords: visceral adipose; rich lipoproteins; triglyceride rich; sympathetic nervous ... See more keywords
Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall.
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DOI: 10.2174/0929867325666180530094819
Abstract: Apolipoprotein B -containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial… read more here.
Keywords: rich lipoproteins; triglyceride rich; arterial wall; lipids arterial ... See more keywords
The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00474
Abstract: Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD,… read more here.
Keywords: rich lipoproteins; triglyceride rich; roles apoc; iii metabolism ... See more keywords