CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF‐4α and DGAT2 expression
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13895
Abstract: C1q/TNF‐related protein 12 (CTRP12) is an antidiabetic adipokine whose circulating levels are reduced in obesity and diabetes. Although partial and complete loss‐of‐function mouse models suggest a role for CTRP12 in modulating lipid metabolism and adiposity,… read more here.
Keywords: ctrp12; export hepatocytes; inhibits triglyceride; expression ... See more keywords
Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.08.013
Abstract: BACKGROUND & AIMS Effective treatments are needed for hepatic steatosis characterized by accumulation of triglycerides in hepatocytes, which leads to hepatocellular carcinoma. MicroRNA 122 (MIR122) is expressed only in the liver, where it regulates lipid metabolism. We… read more here.
Keywords: muscle; liver muscle; mir122; triglyceride synthesis ... See more keywords