The Pharmacokinetics of Triheptanoin and Its Metabolites in Healthy Subjects and Patients With Long-Chain Fatty Acid Oxidation Disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.944
Abstract: Long-chain fatty acid oxidation disorders (LC-FAODs) are a group of life-threatening autosomal recessive disorders caused by defects in nuclear genes encoding mitochondrial enzymes involved in the conversion of dietary long-chain fatty acids into energy. Triheptanoin… read more here.
Keywords: chain; triheptanoin metabolites; fatty acid; long chain ... See more keywords
Effects of triheptanoin (UX007) in patients with long‐chain fatty acid oxidation disorders: Results from an open‐label, long‐term extension study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12313
Abstract: Long‐chain fatty acid oxidation disorders (LC‐FAOD) are autosomal recessive conditions that impair conversion of long‐chain fatty acids into energy, leading to significant clinical symptoms. Triheptanoin is a highly purified, 7‐carbon chain triglyceride approved in the… read more here.
Keywords: chain; duration; study; long chain ... See more keywords
No effect of triheptanoin in patients with phosphofructokinase deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2022.01.012
Abstract: Phosphofructokinase deficiency (PFKD) is a rare disorder of glycogen metabolism. The lack of phosphofructokinase activity blocks the oxidative pathway from glucose and glycogen to pyruvate. Patients suffer from myopathy, exercise intolerance, and myoglobinuria. Currently, there… read more here.
Keywords: treatment; triheptanoin; effect; phosphofructokinase deficiency ... See more keywords
Triheptanoin, an odd-medium-chain triglyceride, impacts brain cognitive function in young and aged mice.
Sign Up to like & getrecommendations! Published in 2023 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2023.2178096
Abstract: ABSTRACTThe brain aging process triggers cognitive function impairment, such as memory loss and compromised quality of life. Cognitive impairment is based on bioenergetic status, with reduced glucose uptake and metabolism in aged brains. Anaplerotic substrates… read more here.
Keywords: lobe; cognitive function; brain; triheptanoin ... See more keywords