TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1‐Mediated Arachidonic Acid Metabolism
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202413674
Abstract: Pancreatic cancer (PC) progresses rapidly, and gemcitabine‐based chemotherapy has brought only limited efficacy. Identifying key drivers and therapeutic targets holds significant clinical value. In this study, through comprehensive analysis of multiple PC databases, this work… read more here.
Keywords: trim21; gemcitabine resistance; arachidonic acid;
TRIM21 promotes ubiquitination of SARS‐CoV‐2 nucleocapsid protein to regulate innate immunity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28719
Abstract: The innate immune response is the first line of host defense against viral infections, but its role in immunity against SARS‐CoV‐2 remains unclear. By using immunoprecipitation coupled with mass spectroscopy, we observed that the E3… read more here.
Keywords: nucleocapsid protein; trim21; cov nucleocapsid; innate ... See more keywords
MiR-99a-3p downregulates TRIM21 to promote gastric cancer development
Sign Up to like & getrecommendations! Published in 2024 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-024-05005-0
Abstract: Gastric cancer (GC) stands as one of the most formidable malignancies worldwide. It is well-established that miRNAs play a crucial role in the initiation and progression of various human cancers. Among these, miR-99a-3p has been… read more here.
Keywords: progression; mir 99a; gastric cancer; 99a downregulates ... See more keywords
TRIM21-mediated ubiquitination of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity
Sign Up to like & getrecommendations! Published in 2024 at "Autophagy"
DOI: 10.1080/15548627.2024.2394308
Abstract: ABSTRACT Long-chain free fatty acids (FFAs) accumulation and oxidative toxicity is a major cause for several pathological conditions. The mechanisms underlying FFA cytotoxicity remain elusive. Here we show that palmitic acid (PA), the most abundant… read more here.
Keywords: cytotoxicity; phosphorylation; palmitic acid; aggregation ... See more keywords
TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2042134
Abstract: ABSTRACT Tripartite motif-containing 21 (TRIM21) has been reported to have a cancer-promoting or anticancer effect in various tumors; however, its role in ovarian cancer (OC) remains to be elucidated. In this study, we explored the… read more here.
Keywords: trim21; cell proliferation; ovarian cancer; expression ... See more keywords
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add6626
Abstract: Despite the rapid utilization of immunotherapy, emerging challenges to the current immune checkpoint blockade need to be resolved. Here, we report that elevation of CD73 levels due to its aberrant turnover is correlated with poor… read more here.
Keywords: cd73 trim21; cd73; trim21; proteolytic regulation ... See more keywords
Tripartite motif-containing protein 21 is involved in IFN-γ-induced suppression of hepatitis B virus by regulating hepatocyte nuclear factors
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.00468-24
Abstract: ABSTRACT The antiviral role of the tripartite motif-containing (TRIM) protein family , a member of the E3-ubiquitin ligase family, has recently been actively studied. Hepatitis B virus (HBV) infection is a major contributor to liver… read more here.
Keywords: hbv; hepatitis virus; tripartite motif; motif containing ... See more keywords
Abstract 4145: TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27 transactivating FOSL1 and promoting the ubiquitination of p27
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4145
Abstract: Our previous studies demonstrated that FOSL1 promotes glioblastoma (GBM) progression and stemness through multiple pathways such as STAT3 and NF-κB signaling. Recently, we identified that FOSL1 physically interacts with the E3 ligaseTRIM21, which is localized… read more here.
Keywords: ubiquitination; transactivating fosl1; p27; trim21 ... See more keywords
TRIM21 mitigates human lung microvascular endothelial cells inflammatory responses to lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2018-0366oc
Abstract: Endothelial cell (EC) inflammation is regarded as an important pathogenic feature of many inflammatory diseases such as acute lung injury and sepsis. Increase in EC inflammation results in neutrophil infiltration from the blood to the… read more here.
Keywords: human lung; microvascular endothelial; trim21; lung microvascular ... See more keywords
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.163795
Abstract: The origin and mechanisms of autoantigen generation in systemic lupus erythematosus (SLE) are poorly understood. Here, we identified SLE neutrophils activated in vivo by IFN as a prominent source of Ro52, also known as tripartite… read more here.
Keywords: trim21; ro52 antibodies; systemic lupus; lupus erythematosus ... See more keywords
7559 TRIM21 Regulates Activation of ERK1/2 to Promote Growth and Drug Resistance in Pituitary Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.1358
Abstract: Abstract Disclosure: Y. Liu: None. F. Liu: None. C. Li: None. T. Zhang: None. L. Xue: None. Z. Wu: None. Objective: To investigate the role of the TRIM family genes in pituitary neuroendocrine tumors (PitNETs)… read more here.
Keywords: pituitary neuroendocrine; none; drug; growth ... See more keywords