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   Articles with "trim21" as a keyword



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TRIM21 promotes ubiquitination of SARS‐CoV‐2 nucleocapsid protein to regulate innate immunity

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recommendations! Published in 2023 at "Journal of Medical Virology"

DOI: 10.1002/jmv.28719

Abstract: The innate immune response is the first line of host defense against viral infections, but its role in immunity against SARS‐CoV‐2 remains unclear. By using immunoprecipitation coupled with mass spectroscopy, we observed that the E3… read more here.

Keywords: nucleocapsid protein; trim21; cov nucleocapsid; innate ... See more keywords

TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2042134

Abstract: ABSTRACT Tripartite motif-containing 21 (TRIM21) has been reported to have a cancer-promoting or anticancer effect in various tumors; however, its role in ovarian cancer (OC) remains to be elucidated. In this study, we explored the… read more here.

Keywords: trim21; cell proliferation; ovarian cancer; expression ... See more keywords

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.add6626

Abstract: Despite the rapid utilization of immunotherapy, emerging challenges to the current immune checkpoint blockade need to be resolved. Here, we report that elevation of CD73 levels due to its aberrant turnover is correlated with poor… read more here.

Keywords: cd73 trim21; cd73; trim21; proteolytic regulation ... See more keywords
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TRIM21 mitigates human lung microvascular endothelial cells inflammatory responses to lipopolysaccharide.

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recommendations! Published in 2019 at "American journal of respiratory cell and molecular biology"

DOI: 10.1165/rcmb.2018-0366oc

Abstract: Endothelial cell (EC) inflammation is regarded as an important pathogenic feature of many inflammatory diseases such as acute lung injury and sepsis. Increase in EC inflammation results in neutrophil infiltration from the blood to the… read more here.

Keywords: human lung; microvascular endothelial; trim21; lung microvascular ... See more keywords
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Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus

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recommendations! Published in 2022 at "JCI Insight"

DOI: 10.1172/jci.insight.163795

Abstract: The origin and mechanisms of autoantigen generation in systemic lupus erythematosus (SLE) are poorly understood. Here, we identified SLE neutrophils activated in vivo by IFN as a prominent source of Ro52, also known as tripartite… read more here.

Keywords: trim21; ro52 antibodies; systemic lupus; lupus erythematosus ... See more keywords
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TRIM21‐mediated proteasomal degradation of SAMHD1 regulates its antiviral activity

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recommendations! Published in 2019 at "EMBO Reports"

DOI: 10.15252/embr.201847528

Abstract: SAMHD1 possesses multiple functions, but whether cellular factors regulate SAMHD1 expression or its function remains not well characterized. Here, by investigating why cultured RD and HEK293T cells show different sensitivity to enterovirus 71 (EV71) infection,… read more here.

Keywords: samhd1; trim21; mediated proteasomal; degradation samhd1 ... See more keywords
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HSP90-regulated CHIP/TRIM21/p21 Axis Involves in the Senescence of Osteosarcoma Cells.

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recommendations! Published in 2023 at "Protein and peptide letters"

DOI: 10.2174/0929866530666230519101148

Abstract: AIMS Investigation of the molecular mechanism of tripartite motif 21 (TRIM21) in osteosarcoma (OS) would shed light on the understanding of the pathogenesis of OS. BACKGROUND OS is the most frequent malignant bone tumor with… read more here.

Keywords: trim21; expression; senescence; p21 axis ... See more keywords
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Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.685913

Abstract: Toxoplasma gondii is an intracellular pathogen that exerts its virulence through inhibiting host’s innate immune responses, which is mainly related to the type II interferon (IFN-γ) response. IFN-γ inducible tripartite motif 21 (TRIM21), an E3… read more here.

Keywords: type; toxoplasma gondii; trim21; immune escape ... See more keywords
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TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1053171

Abstract: Macrophage polarization followed by myocardial infarction (MI) is essential for wound healing. Tripartite motif-containing protein 21 (TRIM21), a member of E3 ubiquitin ligases, is emerging as a mediator in cardiac injury and heart failure. However,… read more here.

Keywords: macrophage polarization; trim21; myocardial infarction; cardiac injury ... See more keywords
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The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24097782

Abstract: Activation of platelet-derived growth factor (PDGF) receptors α and β (PDGFRα and PDGFRβ) at the cell surface by binding of PDGF isoforms leads to internalization of receptors, which affects the amplitude and kinetics of signaling.… read more here.

Keywords: trim21; pdgf; regulates basal; basal levels ... See more keywords
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Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14030589

Abstract: Tripartite-motif 21 (TRIM21) is thought to regulate the type I interferon (IFN) response to virus pathogens and serve as a cytosolic Fc receptor for immunoglobulin. Since herpes simplex virus (HSV)-1 is sensitive to type I… read more here.

Keywords: tripartite motif; hsv; mice; infection ... See more keywords