Nuclear localization signal in TRIM22 is essential for inhibition of type 2 porcine reproductive and respiratory syndrome virus replication in MARC-145 cells
Sign Up to like & getrecommendations! Published in 2019 at "Virus Genes"
DOI: 10.1007/s11262-019-01691-x
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes one of the most economically important swine diseases worldwide. Tripartite motif-containing 22 (TRIM22), a TRIM family protein, has been identified as a crucial restriction factor that… read more here.
Keywords: porcine reproductive; reproductive respiratory; trim22; replication ... See more keywords
Interferon-inducible TRIM22 contributes to maintenance of HIV-1 proviral latency in T cell lines.
Sign Up to like & getrecommendations! Published in 2019 at "Virus research"
DOI: 10.1016/j.virusres.2019.05.009
Abstract: The human immunodeficiency virus type-1 (HIV-1) establishes a state of latent infection in a small number of CD4+ T lymphocytes that, nonetheless, represent a major obstacle to viral eradication. We here show that Tripartite Motif-containing… read more here.
Keywords: latency; interferon inducible; cell lines; hiv ... See more keywords
TRIM22 functions as a scaffold protein for autophagy initiation
Sign Up to like & getrecommendations! Published in 2025 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2025.2498926
Abstract: ABSTRACT Tripartite motif (TRIM) family proteins are increasingly recognized as important regulators of autophagy under various physiological and pathological conditions. TRIM22 has been previously shown to mediate autophagosome-lysosome fusion, but its potential role in earlier… read more here.
Keywords: stages autophagy; scaffold protein; trim22; class iii ... See more keywords
Knockdown of TRIM22 regulates the expression of NF-κB/NLRP3 and alleviates inflammation and renal injury in mice with lupus nephritis.
Sign Up to like & getrecommendations! Published in 2025 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v53i3.1313
Abstract: Lupus nephritis (LN) is a common and clinically challenging complication of the systemic lupus erythematosus (SLE), but effective treatments remain imperative. Tripartite Motif Containing 22 (TRIM22) is a protein involved in various cellular processes, such… read more here.
Keywords: lupus; mice; alleviates inflammation; lupus nephritis ... See more keywords
Tripartite Motif-containing 22 Is Involved in TLR3-mediated Inflammatory Pathway in Rheumatoid Fibroblast-like Synoviocytes
Sign Up to like & getrecommendations! Published in 2025 at "In Vivo"
DOI: 10.21873/invivo.14123
Abstract: Background/Aim: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and cartilage destruction. Tripartite motif-containing 22 (TRIM22) is involved in intracellular signal transduction, protein regulation, and innate immunity through E3 ubiquitin ligase activity.… read more here.
Keywords: fibroblast like; tripartite motif; motif containing; trim22 ... See more keywords
TRIM22 inhibits endometrial cancer progression through the NOD2/NF-kB signaling pathway and confers a favorable prognosis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oncology"
DOI: 10.3892/ijo.2020.5004
Abstract: Endometrial cancer (EnC) is a malignant gynecological tumor commonly observed in developed countries, specifically among post-menopausal women. Although numerous patients with EnC receive promising prognoses, those with advanced or metastatic disease often have a poor… read more here.
Keywords: prognosis; progression; pathway; endometrial cancer ... See more keywords
FOXC1-mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis via NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12820
Abstract: Rheumatoid arthritis (RA) is a common systemic autoimmune disorder of unknown etiology, which threatens public health. The regulatory role of tripartite motif-containing 22 (TRIM22) has been reported in multiple types of cancers and disease, but… read more here.
Keywords: signaling pathway; proliferation; rheumatoid arthritis; expression ... See more keywords