E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase‐1/IL‐1β‐mediated pyroptosis in endometriosis
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DOI: 10.1002/cbin.11592
Abstract: Endometriosis is an inflammation‐dependent disease that shares similarities with malignant tumors including attachment and infiltration. Tripartite motif‐containing 24 (TRIM24) has been illustrated in inflammatory responses and gynecological tumors, and Nod‐like receptor protein 3 (NLRP3) inflammasome… read more here.
Keywords: trim24; nlrp3 caspase; endometriosis; mediated pyroptosis ... See more keywords
TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
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DOI: 10.1038/s41467-018-07475-5
Abstract: TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa… read more here.
Keywords: trim24; prostate cancer; trim28; pca ... See more keywords
Abstract 981: The design and characterization of a selective TRIM24 degrader
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-981
Abstract: A fundamental biological understanding of the individual contributions of functional domains within multidomain proteins is critical to inform therapeutic approaches to targeting mechanisms driving human disease. TRIM24 is a multi-domain protein that has been broadly… read more here.
Keywords: protein; trim24; degrader; selective trim24 ... See more keywords
Abstract 787: Cytosolic TRIM24 characterizes an aggressive subset of ER- PR- and TP53 mutant breast cancer
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DOI: 10.1158/1538-7445.am2018-787
Abstract: Introduction: Tripartite Motif Containing 24 (TRIM24) is a PhD/Bromodomain containing steroid receptor co-activator that targets p53 for proteosomal degradation, transforms human mammary epithelial cells, and promotes treatment resistance in preclinical models. While bromodomain inhibitors and… read more here.
Keywords: trim24; breast cancer; cancer; tp53 mutant ... See more keywords
TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5604
Abstract: Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression. However, the role of TRIM24 in gastric cancer (GC) and the mechanisms underlying the dysregulated expression of TRIM24 remain to be fully elucidated. In… read more here.
Keywords: trim24; gastric cancer; catenin signaling; catenin ... See more keywords