MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation
Sign Up to like & getrecommendations! Published in 2017 at "Oncogenesis"
DOI: 10.1038/oncsis.2017.21
Abstract: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer death in the world. Fructose-1,6-biphosphatase (FBP1), a rate-limiting enzyme in gluconeogenesis, has been identified recently as a tumor suppressor in HCC and other cancer… read more here.
Keywords: degradation; hcc; trim28; fbp1 degradation ... See more keywords
TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07475-5
Abstract: TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa… read more here.
Keywords: trim24; prostate cancer; trim28; pca ... See more keywords
Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20434-3
Abstract: The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 ( Trim28 ), a gene… read more here.
Keywords: deletion trim28; sex specific; trim28; committed adipocytes ... See more keywords
A novel role of TRIM28 B box domain in L1 retrotransposition and ORF2p-mediated cDNA synthesis
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad247
Abstract: Abstract The long interspersed element 1 (LINE-1 or L1) integration is affected by many cellular factors through various mechanisms. Some of these factors are required for L1 amplification, while others either suppress or enhance specific… read more here.
Keywords: box domain; retrotransposition; cdna synthesis; trim28 box ... See more keywords
TRIM28 Serves As a Key Regulator of Protein Homeostasis and Mediates Proteasome Inhibitor Resistance in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-204159
Abstract: Introduction: The maintenance of intracellular protein homeostasis is a critical biological process necessary for the survival of multiple myeloma (MM) cells. Tripartite motif (TRIM) proteins, a subfamily of the RING-type E3 ubiquitin ligase family, are… read more here.
Keywords: trim28; myeloma; role; protein homeostasis ... See more keywords
TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13273
Abstract: The expression of Tripartite motif-containing protein 28 (TRIM28)/Krüppel-associated box (KRAB)-associated protein 1 (KAP1), is elevated in at least 14 tumor types, including solid and hematopoietic tumors. High level of TRIM28 is associated with triple-negative subtype… read more here.
Keywords: protein; breast; trim28; cancer ... See more keywords
Resveratrol Alleviates Ischemia-Reperfusion-Induced Neuronal Damage by Inhibiting NR3C2-Mediated TRIM28 Expression.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of integrative neuroscience"
DOI: 10.31083/jin31375
Abstract: BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) exacerbates neuronal damage through mechanisms including apoptosis and autophagy dysregulation. Resveratrol (Res), a natural polyphenol with neuroprotective properties, may alleviate CIRI-induced damage by modulating key signaling pathways. This study investigates… read more here.
Keywords: reperfusion; damage; trim28; neuronal damage ... See more keywords
SNHG8 Promotes the Progression of Epstein–Barr Virus-Associated Gastric Cancer via Sponging miR-512-5p and Targeting TRIM28
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.734694
Abstract: SNHG8, a family member of small nucleolar RNA host genes (SNHG), has been reported to act as an oncogene in gastric carcinoma (GC). However, its biological function in Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) remains… read more here.
Keywords: snhg8; trim28; mir 512; expression ... See more keywords
Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126839
Abstract: TRIM28 is a scaffold protein that interacts with DNA-binding proteins and recruits corepressor complexes to cause gene silencing. TRIM28 contributes to physiological functions such as cell growth and differentiation. In the chronic myeloid leukemia cell… read more here.
Keywords: cell; cell proliferation; k562; trim28 ... See more keywords
Tripartite motif containing 28 (TRIM28) promotes the growth and migration of endometrial carcinoma cells by regulating the AKT/mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "General physiology and biophysics"
DOI: 10.4149/gpb_2021009
Abstract: Although the medical science has been developed for decades, the molecular mechanism of endometrial cancer (EC) is not yet completely clear. Previous studies have shown that the tripartite motif containing 28 (TRIM28) plays a crucial… read more here.
Keywords: growth migration; cell; akt mtor; trim28 ... See more keywords