The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102058
Abstract: Tripartite motif (TRIM) 31 has been implicated in diverse biological and pathological conditions. However, whether TRIM31 plays a role in ischemic stroke progression is not clarified. Here we demonstrated that TRIM31 was significantly downregulated in… read more here.
Keywords: trim31; ubiquitin ligase; brain; tigar ... See more keywords
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53‐AMPK axis
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.04.013
Abstract: ABSTRACT Anoikis‐resistance is an essential feature of cancer cells to obtain successful metastasis, whereas the molecular mechanism involved in this process of hepatocellular carcinoma (HCC) cells is not fully understood. Here we demonstrated that tripartite… read more here.
Keywords: trim31; hcc cells; anoikis; resistance ... See more keywords
TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1–TSC2 complex
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/onc.2017.349
Abstract: Tripartite motif (TRIM) 31 is a member of the tripartite motif-containing protein family, and TRIM family proteins are involved in a broad range of biological and pathological processes. However, the role of TRIM31 in hepatocellular… read more here.
Keywords: hepatocellular carcinoma; trim31; tsc1 tsc2; progression ... See more keywords
The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28641-w
Abstract: Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). However, no effective therapeutic strategies are available, practically because our understanding of… read more here.
Keywords: liver disease; non alcoholic; rhbdf2; disease ... See more keywords
E3-ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.281955
Abstract: Hematopoietic stem cells (HSCs) are kept in a quiescent state to maintain their self-renewal capacity. Proper regulation of cyclin-dependent kinases (CDKs) and cyclin proteins is critical for the maintenance of HSC homeostasis. Here, we found… read more here.
Keywords: trim31; cell; leukemia; hematopoietic stem ... See more keywords
TRIM31: A molecule with a dual role in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1047177
Abstract: Tripartite motif (TRIM) 31 is a new member of the TRIM family and functions as an E3 ubiquitin ligase. Abnormal TRIM31 expression leads to a variety of pathological conditions, such as cancer, innate immunity diseases,… read more here.
Keywords: role trim31; cancer; trim31 molecule; trim31 ... See more keywords
TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Neoplasma"
DOI: 10.4149/neo_2019_190106n21
Abstract: This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and Western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high… read more here.
Keywords: migration glioma; trim31; proliferation invasion; glioma ... See more keywords