Overexpression of TRIM32 promotes pancreatic β‐cell autophagic cell death through Akt/mTOR pathway under high glucose conditions
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DOI: 10.1002/cbin.11897
Abstract: Type 2 diabetes mellitus (T2DM) is a growing worldwide epidemic and is characterized by progressive pancreatic β‐cell dysfunction and insulin resistance. Tripartite motif protein 32 (TRIM32) belongs to the TRIM family protein and has been… read more here.
Keywords: cell; pancreatic cell; akt mtor; high glucose ... See more keywords
Knockdown of TRIM32 Protects Hippocampal Neurons from Oxygen–Glucose Deprivation-Induced Injury
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DOI: 10.1007/s11064-019-02857-7
Abstract: Tripartite motif 32 (TRIM32) is a member of TRIM family that plays a potential role in neural regeneration. However, the biological function of TRIM32 in cerebral ischemia reperfusion injury has not been investigated. In the… read more here.
Keywords: hippocampal neurons; knockdown trim32; glucose deprivation; oxygen glucose ... See more keywords
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification
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DOI: 10.1038/s41418-018-0144-1
Abstract: The balance between stem cell maintenance and differentiation has been proposed to depend on antagonizing ubiquitination and deubiquitination reactions of key stem cell transcription factors (SCTFs) mediated by pairs of E3 ubiquitin ligases and deubiquitinating… read more here.
Keywords: stem cell; cell fate; stem; cell ... See more keywords
TRIM32 promotes inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes
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DOI: 10.1111/sji.12876
Abstract: Rheumatoid arthritis (RA) is a worldwide autoimmune disease. The study of its aetiology and mechanism has always been a focus topic in medicine. This research was designed to investigate the effect of E3 ubiquitin ligase… read more here.
Keywords: inflammatory responses; fibroblast like; like synoviocytes; trim32 promotes ... See more keywords
Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence
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DOI: 10.1371/journal.pone.0251279
Abstract: TRIM32 is an E3 ligase implicated in diverse biological pathways and pathologies such as muscular dystrophy and cancer. TRIM32 are expressed both as full-length proteins, and as a truncated protein. The mechanisms for regulating these… read more here.
Keywords: acetylation; isoform; trim32; pest sequence ... See more keywords