TRIM33 is essential for osteoblast proliferation and differentiation via BMP pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25769
Abstract: Tripartite motif containing 33 (TRIM33) functions both as a positive and negative regulator of the TGF‐β/BMP pathway in tumors; however, its effect and mechanism during osteoblast proliferation and differentiation, which involves the TGF‐β/BMP pathway is… read more here.
Keywords: osteoblast proliferation; trim33; differentiation; bmp pathway ... See more keywords
Role of TRIM33 in Wnt signaling during mesendoderm differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9129-3
Abstract: Tripartite motif 33 (TRIM33), a member of the transcription intermediate factor 1 (TIF1) family of transcription cofactors, mediates transforming growth factor-beta (TGF-β) signaling through its PHD-Bromo cassette in mesendoderm differentiation during early mouse embryonic development.… read more here.
Keywords: mesendoderm differentiation; trim33; wnt signaling; role trim33 ... See more keywords
TRIM33 promotes spring viremia of carp virus replication by degrading the antiviral protein viperin_sv1
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.736837
Abstract: Abstract TRIM33 is a member of the tripartite motif (TRIM) superfamily which contributes to regulate a multitude of cellular processes, including innate immune responses. Viperin_sv1 has recently been identified as a novel splice variant of… read more here.
Keywords: trim33; replication; viperin; viperin sv1 ... See more keywords
TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.05.037
Abstract: Background Mature myeloid cells play a crucial role in Crohn's disease (CD) but the molecular players that regulate their functions in CD are not fully characterized. We and others have shown that TRIM33 is involved… read more here.
Keywords: role trim33; colonic inflammation; trim33; inflammation ... See more keywords
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00266
Abstract: TRIM33 is a member of the tripartite motif (TRIM) family of proteins, some of which possess E3 ligase activity and are involved in the ubiquitin-dependent degradation of proteins. Four of the TRIM family proteins, TRIM24… read more here.
Keywords: identification histone; trim33; ligands trim33; histone peptide ... See more keywords
Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08810-0
Abstract: Productive HIV-1 replication requires viral integrase (IN), which catalyzes integration of the viral genome into the host cell DNA. IN, however, is short lived and is rapidly degraded by the host ubiquitin-proteasome system. To identify… read more here.
Keywords: hiv infection; degradation; microscopy; viral integrase ... See more keywords
TRIM33 Modulates Inflammation and Airway Remodeling of PDGF-BB-Induced Airway Smooth-Muscle Cells by the Wnt/β-Catenin Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000524574
Abstract: Asthma is a chronic airway disease involving airway inflammation and remodeling. Studies showed that tripartite motif-containing protein 33 (TRIM33) regulated natural immunity, inflammation, and pulmonary fibrosis. However, the role and regulatory mechanism of TRIM33 in… read more here.
Keywords: trim33; wnt catenin; airway remodeling; inflammation airway ... See more keywords
TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202153468
Abstract: Androgen receptor (AR) is a master transcription factor that drives prostate cancer (PCa) development and progression. Alterations in the expression or activity of AR coregulators significantly impact the outcome of the disease. Using a proteomics… read more here.
Keywords: tumor growth; skp2 mediated; drives prostate; trim33 ... See more keywords