Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.
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DOI: 10.1080/15548627.2021.1965421
Abstract: Epidemiological and clinical studies have shown that exposure to particulate matter (PM) is associated with an increased incidence of lung cancer and metastasis. However, the underlying mechanism remains unclear. Here, we demonstrated the central role… read more here.
Keywords: traf6; metastasis; particulate matter; trim37 ... See more keywords
miR‐942‐5p prevents sepsis‐induced acute lung injury via targeting TRIM37
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DOI: 10.1111/iep.12413
Abstract: MicroRNAs (miRNAs) have been demonstrated to play pivotal roles in the pathogenesis of sepsis‐induced acute lung injury (ALI). In this work, we aimed to clarify the potential role and the underlying mechanism of miR‐942‐5p in… read more here.
Keywords: mir 942; acute lung; trim37; injury ... See more keywords
TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease
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DOI: 10.1126/sciadv.adl2036
Abstract: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by preferential neuronal loss in the striatum. The mechanism underlying striatal selective neurodegeneration remains unclear, making it difficult to develop effective treatments for HD. In… read more here.
Keywords: disease; trim37; huntington disease; primate specific ... See more keywords
Abstract 4998: Selective PLK4 inhibition demonstrates synthetic lethality in TRIM37 amplified neuroblastoma and breast cancer models while less selective inhibitors do not
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DOI: 10.1158/1538-7445.am2023-4998
Abstract: Amplification and copy number gains of the 17q23 amplicon are common in breast cancer and neuroblastoma and have been associated with early relapse and poor prognosis (Ganesan et al 2012; Takita et al. 2017). A… read more here.
Keywords: inhibition; less selective; plk4; trim37 ... See more keywords
Abstract 1992: A novel RB1 E3 ligase TRIM37 contributes to palbociclib resistance in breast cancer
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DOI: 10.1158/1538-7445.am2024-1992
Abstract: The tripartite motif-containing 37 (TRIM37) is a RING finger E3 ubiquitin ligase and is a poor prognostic factor in breast cancer patients. The gene is located in chromosome 17q23, a region amplified in up to… read more here.
Keywords: cancer; resistance; trim37; rb1 protein ... See more keywords
TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin
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DOI: 10.7554/elife.62640
Abstract: TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin.… read more here.
Keywords: trim37 prevents; formation; trim37; protein assemblies ... See more keywords