TRIM44 enhances autophagy via SQSTM1 oligomerization in response to oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-67832-x
Abstract: The deubiquitinase tripartite motif containing 44 (TRIM44) plays a critical role in linking the proteotoxic stress response with autophagic degradation, which is significant in the context of cancer and neurological diseases. Although TRIM44 is recognized… read more here.
Keywords: stress; oxidative stress; enhances autophagy; trim44 ... See more keywords
PARP1-TRIM44-MRN loop dictates the response to PARP inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae756
Abstract: Abstract PARP inhibitors (PARPi) show selective efficacy in tumors with homologous recombination repair (HRR)-defects but the activation mechanism of HRR pathway in PARPi-treated cells remains enigmatic. To unveil it, we searched for the mediator bridging… read more here.
Keywords: parp inhibitors; mrn complex; mrn; parp1 trim44 ... See more keywords
Aberrant expression of TRIM44, transcriptionally regulated by KLF9, contributes to the process of diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06436-z
Abstract: Diabetic retinopathy (DR) is the common cause of diabetic vascular complications and it causes blindness. Until now, there are still some patients with DR who lack effective treatment. Tripartite motif containing 44 (TRIM44) has been… read more here.
Keywords: expression trim44; diabetes induced; aberrant expression; diabetic retinopathy ... See more keywords
Battling quiescence for tumor eradication: too good to be true?
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26452
Abstract: Efforts to differentiate mechanisms underlying tumor quiescence and proliferation have occurred mostly in leukemia [1], and in hormone-driven cancers of the breast [2] or the prostate [3, 4]. In our previous study, we isolated quiescent… read more here.
Keywords: quiescent cells; pkh; quiescence; trim44 ... See more keywords
Knockdown of TRIM44 inhibits the progression of ovarian cancer and is related to the FOXM1-EZH2 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-2915
Abstract: Background Tripartite motif-containing protein 44 (TRIM44) was recently identified as a novel oncogene that is overexpressed in several types of human cancers. However, the biological functions of TRIM44 in epithelial ovarian cancer (EOC) remain unclear.… read more here.
Keywords: foxm1 ezh2; trim44; ovarian cancer; ezh2 signaling ... See more keywords
Circular RNA circ_0020123 Promotes Non-Small Cell Lung Cancer Progression Through miR-384/TRIM44 Axis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Management and Research"
DOI: 10.2147/cmar.s278913
Abstract: Background It was reported that circular RNAs (circRNAs) and microRNAs (miRNAs) were related to non-small cell lung cancer (NSCLC) development. However, the detailed mechanisms of circ_0020123 and miR-384 in NSCLC are elusive. Methods QRT-PCR and… read more here.
Keywords: cancer; cell; trim44; mir 384 ... See more keywords
LncRNA ELDR promotes bladder cancer malignant progression by regulating the miR-1343-3p/TRIM44 axis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1685792
Abstract: Introduction Bladder cancer (BCa) is one of the most prevalent genitourinary malignancies with high recurrence worldwide. A lack of reliable prognostic biomarkers and effective therapeutic targets hinders its treatment. Emerging evidence indicates that long noncoding… read more here.
Keywords: 1343 trim44; eldr; trim44; bca ... See more keywords
TRIM44 promotes BRCA1 functions in HR repair to induce Cisplatin Chemoresistance in Lung Adenocarcinoma by Deubiquitinating FLNA
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.71283
Abstract: Tripartite motif-containing 44 (TRIM44) has recently been implicated in various pathological processes in numerous cancers, including lung adenocarcinoma (LUAD); however, its functional roles in chemoresistance are poorly understood. Herein, TRIM44 knockdown sensitized LUAD cells to… read more here.
Keywords: lung adenocarcinoma; luad; trim44; cisplatin chemoresistance ... See more keywords