RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0198-0
Abstract: TRIM5α is a cytoplasmic restriction factor that blocks post-entry retroviral infection. Evidence suggests that its antiviral activity can be regulated by SUMO, but how this is achieved remains unknown. Here, we show that TRIM5α forms… read more here.
Keywords: sumoylation; ranbp2; antiviral activity; trim5 ... See more keywords
The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2084863
Abstract: ABSTRACT The protein TRIM5 is under intensive investigation related to its roles in antiviral defense, yet its underlying mechanisms of action remain elusive. In our study, we performed an unbiased identification of TRIM5-interacting partners and… read more here.
Keywords: mitochondrial quality; mitochondrial damage; quality control; trim5 ... See more keywords
Cyclophilin A potentiates TRIM5α inhibition of HIV-1 nuclear import without promoting TRIM5α binding to the viral capsid
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182298
Abstract: The host immunophilin cyclophilin A (CypA) binds to the capsid protein (CA) of HIV-1 and regulates its infectivity. Depending on the target cell type, CypA can either promote or inhibit HIV-1 infection. The ability of… read more here.
Keywords: hiv; infection; trim5; cypa ... See more keywords
Not so unique to Primates: The independent adaptive evolution of TRIM5 in Lagomorpha lineage
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DOI: 10.1371/journal.pone.0226202
Abstract: The plethora of restriction factors with the ability to inhibit the replication of retroviruses have been widely studied and genetic hallmarks of evolutionary selective pressures in Primates have been well documented. One example is the… read more here.
Keywords: pryspry domain; evolution; unique primates; trim5 ... See more keywords
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α
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DOI: 10.1371/journal.ppat.1009017
Abstract: TRIM5α is a key cross-species barrier to retroviral infection, with certain TRIM5 alleles conferring increased risk of HIV-1 infection in humans. TRIM5α is best known as a species-specific restriction factor that directly inhibits the viral… read more here.
Keywords: trim5; autophagy machinery; canonical role; non canonical ... See more keywords
A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1168589
Abstract: The intracellular restriction factor TRIM5α inhibits endogenous LINE-1 retroelements. It induces innate immune signaling cascades upon sensing of cytoplasmic LINE-1 complexes, thereby underlining its importance for protecting the human genome from harmful retrotransposition events. Here,… read more here.
Keywords: frequent snp; line elements; innate immune; line ... See more keywords
Regulation of Epstein-Barr Virus Minor Capsid Protein BORF1 by TRIM5α
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315340
Abstract: TRIM5α is a host anti-retroviral restriction factor that destroys human immunodeficiency virus (HIV) virions and triggers innate immune signaling. TRIM5α also mediates the autophagic degradation of target proteins via TRIMosome formation. We previously showed that… read more here.
Keywords: capsid protein; trim5; epstein barr; capsid ... See more keywords
Editing of the TRIM5 Gene Decreases the Permissiveness of Human T Lymphocytic Cells to HIV-1
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v13010024
Abstract: Tripartite-motif-containing protein 5 isoform α (TRIM5α) is a cytoplasmic antiretroviral effector upregulated by type I interferons (IFN-I). We previously showed that two points mutations, R332G/R335G, in the retroviral capsid-binding region confer human TRIM5α the capacity… read more here.
Keywords: hiv; trim5 gene; trim5; inhibition ... See more keywords
Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13020320
Abstract: Human immunodeficiency virus-1 (HIV-1) persists as a global health concern, with an incidence rate of approximately 2 million, and estimated global prevalence of over 35 million. Combination antiretroviral treatment is highly effective, but HIV-1 patients… read more here.
Keywords: hiv; trim5; hiv restriction; human trim5 ... See more keywords