TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59129-y
Abstract: Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many other mammals. In contrast to what one would expect for such a non-conserved factor, TRIM52 loss compromises cell fitness. We… read more here.
Keywords: fitness; control; multiple giant; giant ligases ... See more keywords
TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL‐1β‐induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18244
Abstract: To explore the mechanism of tripartite motif 52 (TRIM52) in the progression of temporomandibular joint osteoarthritis (TMJOA). Gene and protein expression were tested by quantitative real‐time polymerase chain reaction and western blot, respectively. The levels… read more here.
Keywords: trim52; proliferation inflammatory; oxidative stress; proliferation ... See more keywords
TRIM52 promotes colorectal cancer cell proliferation through the STAT3 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0775-4
Abstract: BackgroundThe tripartite motif (TRIM) family proteins are implicated in the pathogenesis of various human malignancies. The up-regulation and oncogenic roles of TRIM52 have been reported in hepatocellular carcinoma. In the current study, we aimed to… read more here.
Keywords: cell proliferation; trim52; expression; cell ... See more keywords
TRIM52 aggravated inflammation and pyroptosis in dextran sulfate sodium-induced inflammatory bowel disease through activation of the TLR4/NF-κBs pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v51i1.737
Abstract: INTRODUCTION Inflammatory bowel disease (IBD), which mainly leads to diarrhea, fatigue, stool blood, abdominal pain, and cramping, is threatening public health. Tripartite motif-containing 52 (TRIM52) has been reported to play an important role in inflammatory… read more here.
Keywords: disease; dss induced; inflammation pyroptosis; trim52 ... See more keywords
Human tripartite motif protein 52 is required for cell context-dependent proliferation
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24422
Abstract: Tripartite motif (TRIM) proteins have been shown to play important roles in cancer development and progression by modulating cell proliferation or resistance from cell death during non-homeostatic stress conditions found in tumor micro-environments. In this… read more here.
Keywords: human tripartite; proliferation; tripartite motif; trim52 ... See more keywords
TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology reports"
DOI: 10.3892/or.2019.7110
Abstract: As a major cause of cancer‑associated mortalities, lung cancer is frequently diagnosed in males and females with an incidence ratio of 2.1:1. Tripartite motif 52 (TRIM52), an E3 ubiquitin ligase, has been reported to be… read more here.
Keywords: cancer; proliferation invasiveness; trim52; lung cancer ... See more keywords