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   Articles with "trim56" as a keyword



TRIM56 Aggravates Cerebral Ischemia-Reperfusion Injury via Inhibiting KLF4-Activated Ferroptosis Signaling.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202509906

Abstract: Cerebral ischemia-reperfusion (I/R) injury often causes significant neuronal damage, neurological deficits, and long-term disability. This study investigates the role of tripartite motif-protein 56 (TRIM56) in cerebral I/R injury and elucidates the underlying mechanisms. Here, a… read more here.

Keywords: ischemia reperfusion; trim56; cerebral ischemia; reperfusion injury ... See more keywords

Poly r(C) Binding Protein 1 Regulates Posttranscriptional Expression of the Ubiquitin Ligase TRIM56 in Ovarian Cancer

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recommendations! Published in 2019 at "IUBMB Life"

DOI: 10.1002/iub.1948

Abstract: Our earlier work has shown that the E3 ligase TRIM56 messenger RNA (mRNA) level and vimentin protein expression followed an inverse correlation in ovarian carcinoma patients; however, the regulatory mechanisms underlying TRIM56 expression is unclear.… read more here.

Keywords: protein; skov cells; trim56; expression ... See more keywords

Comprehensive analysis of TRIM56’s prognostic value and immune infiltration in Pan-Cancer

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-97856-w

Abstract: TRIM56 plays a role in tumor development through the ubiquitination of several key substrate molecules. However, its relationship with tumor prognosis and immune infiltration remains unclear. The expression and localization of TRIM56 were analyzed from… read more here.

Keywords: trim56; tumor; immune infiltration; trim56 expression ... See more keywords

TRIM56-mediated production of type I interferon inhibits intracellular replication of Rickettsia rickettsii

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recommendations! Published in 2024 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.03695-23

Abstract: ABSTRACT Rickettsia rickettsii (R. rickettsii), the causative agent of Rocky Mountain spotted fever (RMSF), is the most pathogenic member among Rickettsia spp. Previous studies have shown that tripartite motif-containing 56 (TRIM56) E3 ligase-induced ubiquitination of… read more here.

Keywords: host; trim56; interferon; intracellular replication ... See more keywords

Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14010089

Abstract: The physiologic function of tripartite motif protein 56 (TRIM56), a ubiquitously expressed E3 ligase classified within the large TRIM protein family, remains elusive. Gene knockdown studies have suggested TRIM56 as a positive regulator of the… read more here.

Keywords: double stranded; stranded rna; rna cytosolic; extracellular double ... See more keywords