TRIM59, amplified in ovarian cancer, promotes tumorigenesis through the MKP3/ERK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29478
Abstract: Tripartite motif containing 59 (TRIM59) functions as an oncoprotein in various human cancers including ovarian cancer. In this study, we found that TRIM59 gene amplification was prevalent in ovarian cancer tissues, and its amplification was… read more here.
Keywords: trim59; mkp3 erk; ovarian cancer; erk pathway ... See more keywords
TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.130
Abstract: The tripartite motif (TRIM) protein family are implicated in a wide array of cellular processes, including cell growth, differentiation, apoptosis and inflammation. This study aimed to investigate the specific function of TRIM59 in chondrocytes and… read more here.
Keywords: jak2 stat3; matrix; signaling pathway; trim59 ... See more keywords
TRIM59: A membrane protein expressed on Bacillus Calmette-Guérin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111590
Abstract: Bacillus Calmette-Guérin (BCG)-activated macrophages (BAMs) have anti-tumor effects, especially on fibrosarcoma cells. However, the mechanism governing this process has not been elucidated to date. TRIM59 is an up-regulated membrane protein expressed on the surface of… read more here.
Keywords: activated macrophages; trim59; bacillus calmette; fibrosarcoma cells ... See more keywords
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12001-2
Abstract: Despite the development of adjuvant therapies, glioblastoma (GBM) patients remain incurable, thus justifying the urgent need of new therapies. CDK5 plays a critical role in GBM and is a potential target for GBM. However, the… read more here.
Keywords: trim59; cdk5 dependent; nuclear translocation; tumorigenicity ... See more keywords
The role of TRIM59 in immunity and immune-related diseases.
Sign Up to like & getrecommendations! Published in 2022 at "International reviews of immunology"
DOI: 10.1080/08830185.2022.2102618
Abstract: TRIM59 is a member of the tripartite motif containing (TRIM) protein family. It functions as an E3 ubiquitin ligase through its RING domain and is expressed by multiple types of cells. Physiogically, TRIM59 is involved… read more here.
Keywords: immunity immune; trim59 immunity; immune; role trim59 ... See more keywords
Potential value of tripartite motif-containing 59 as a biomarker for predicting the prognosis of patients with lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000026868
Abstract: Abstract Background: In recent years, related studies have revealed that tripartite motif-containing 59 (TRIM59) is related to the prognosis of lung cancer. However, these results have not been proved by any evidence. Therefore, this study… read more here.
Keywords: prognosis; lung cancer; trim59; cancer ... See more keywords
TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.6467
Abstract: Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in… read more here.
Keywords: cell lung; trim59; lung cancer; cancer ... See more keywords