A congenital hydrocephalus‐causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202255843
Abstract: Congenital hydrocephalus (CH) is a major cause of childhood morbidity. Mono‐allelic mutations in Trim71, a conserved stem‐cell‐specific RNA‐binding protein, cause CH; however, the molecular basis for pathogenesis mediated by these mutations remains unknown. Here, using… read more here.
Keywords: cell; stem cell; trim71; congenital hydrocephalus ... See more keywords
TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.658966
Abstract: Mutations affecting the germline can result in infertility or the generation of germ cell tumors (GCT), highlighting the need to identify and characterize the genes controlling germ cell development. The RNA-binding protein and E3 ubiquitin… read more here.
Keywords: germ cell; trim71; infertility; cell ... See more keywords