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   Articles with "trim8" as a keyword



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The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis

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recommendations! Published in 2017 at "Hepatology"

DOI: 10.1002/hep.28971

Abstract: Tripartite motif 8 (TRIM8), an E3 ligase ubiquitously expressed in various cells, is closely involved in innate immunity. However, its role in nonalcoholic steatohepatitis is largely unknown. Here, we report evidence that TRIM8 is a… read more here.

Keywords: trim8; tripartite motif; steatohepatitis; insulin resistance ... See more keywords
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Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway

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recommendations! Published in 2022 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2022.2096644

Abstract: Abstract Context Salvianolic acid B (SalB) can attenuate myocardial ischemia/reperfusion (I/R) injury, but the mechanisms are not entirely known. Objective Our study investigates if SalB protects cardiomyocytes against I/R injury by regulating Tripartite motif (TRIM)… read more here.

Keywords: trim8 gpx1; trim8; salvianolic acid; treatment ... See more keywords
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TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

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recommendations! Published in 2019 at "Science Advances"

DOI: 10.1126/sciadv.aax3511

Abstract: TRIM8 and Pin1 oppositely control IRF7-induced interferon production. Plasmacytoid dendritic cells (pDCs) play a crucial role in antiviral innate immunity through their unique capacity to produce large amounts of type I interferons (IFNs) upon viral… read more here.

Keywords: ifn response; dendritic cells; plasmacytoid dendritic; trim8 ... See more keywords
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TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance

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recommendations! Published in 2021 at "Biomedicines"

DOI: 10.3390/biomedicines9030241

Abstract: Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the population and, as all malignant tumors, often develops resistance to chemotherapies with consequent tumor growth and spreading leading to the patient’s… read more here.

Keywords: promising therapeutic; trim proteins; colorectal cancer; trim8 ... See more keywords