Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.09.024
Abstract: Summary Recent efforts toward HIV vaccine development include the design of immunogens that can engage B cell receptors with the potential to affinity mature into broadly neutralizing antibodies (bnAbs). V2-apex bnAbs, which bind a protein-glycan… read more here.
Keywords: hiv; hiv envelope; neutralizing antibodies; wild type ... See more keywords
Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110436
Abstract: HIV-1 clade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold-specific antibodies (protective correlates from RV144 human trial) are urgently needed due to the prevalence of this clade in the most impacted regions worldwide.… read more here.
Keywords: scaffold antibodies; clade; autologous neutralizing; v1v2 scaffold ... See more keywords
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.03.017
Abstract: &NA; Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env)… read more here.
Keywords: apex; antibody; structure; broadly neutralizing ... See more keywords
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.10.008
Abstract: Summary The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein determinants are occluded by self-N-glycan shielding, limiting B cell recognition of the… read more here.
Keywords: envelope; trimer; neutralizing antibodies; vaccination glycan ... See more keywords
Synthesis of epigallocatechin trimer, (epigallocatechin)2-epicatechin, and (epigallocatechin)2-catechin via a Lewis acid mediated one-pot condensation and their antitumor activities in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.089
Abstract: Abstract Syntheses of epigallocatechin trimer, (epigallocatechin)2-epicatechin and (epigallocatechin)2-catechin were achieved. The key condensation to form the proanthocyanidin trimer derivatives was accomplished in a one-pot procedure using a dimeric epigallocatechin electrophile, which was prepared in situ… read more here.
Keywords: epigallocatechin epicatechin; epigallocatechin trimer; trimer; condensation ... See more keywords
Probing Intermolecular Interactions within the Amyloid β Trimer Using a Tethered Polymer Nanoarray.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00387
Abstract: Amyloid oligomers are considered the most neurotoxic species of amyloid aggregates. Spontaneous assembly of amyloids into aggregates is recognized as a major molecular mechanism behind Alzheimer's disease and other neurodegenerative disorders involving protein aggregation. Characterization… read more here.
Keywords: chemistry; force; intermolecular interactions; probing intermolecular ... See more keywords
Palladium Acetate Trimer: Understanding Its Ligand-Induced Dissociation Thermochemistry Using Isothermal Titration Calorimetry, X-ray Absorption Fine Structure, and 31P Nuclear Magnetic Resonance
Sign Up to like & getrecommendations! Published in 2018 at "Organometallics"
DOI: 10.1021/acs.organomet.8b00787
Abstract: Palladium acetate trimer, Pd3(OAc)6, is a common precursor for Pd nanoparticle synthesis and an important precatalyst for homogeneous catalysis reactions. Added ligands (L, e.g., phosphines) are well-known to dissociate the Pd3(OAc)6 trimer into Pd(OAc)2 monomers… read more here.
Keywords: ray absorption; titration calorimetry; isothermal titration; palladium acetate ... See more keywords
Visible Light-Driven Dye-Sensitized Photocatalytic Hydrogen Production by Porphyrin and its Cyclic Dimer and Trimer: Effect of Multi-Pyridyl-Anchoring Groups on Photocatalytic Activity and Stability
Sign Up to like & getrecommendations! Published in 2018 at "ACS Applied Energy Materials"
DOI: 10.1021/acsaem.8b01113
Abstract: The monomer, dimer, and trimer of 5,15-diphenyl-10,20-di(pyridin-4-yl)porphyrin are used to investigate the multianchoring effect on TiO2 for visible light-driven photocatalytic hydrogen production in a water medium. Further, the porphyrin trimer is prepared and analyzed by… read more here.
Keywords: hydrogen production; dimer; spectroscopy; trimer ... See more keywords
Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00363
Abstract: Oligomers of the amyloid β (Aβ) protein play a critical role in the pathogenesis of Alzheimer's disease. However, their heterogeneity and lability deter the identification of their tertiary structures and mechanisms of action. Aβ trimers… read more here.
Keywords: cytotoxicity; trimer; trimer models; propeller ... See more keywords
Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09518-1
Abstract: TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) has long been considered a tantalizing target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing its functional receptors… read more here.
Keywords: trimer tag; vivo; trail; trimer ... See more keywords
Long-lived trimers in a quasi-two-dimensional Fermi system
Sign Up to like & getrecommendations! Published in 2018 at "Physical Review A"
DOI: 10.1103/physreva.97.042711
Abstract: We consider the problem of three distinguishable fermions confined to a quasi-two-dimensional (quasi-2D) geometry, where there is a strong harmonic potential in one direction. We go beyond previous theoretical work and investigate the three-body bound… read more here.
Keywords: quasi two; lived trimers; trimer; two dimensional ... See more keywords