An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity
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DOI: 10.1158/1078-0432.ccr-20-4625
Abstract: Purpose: The induction of 4-1BB signaling by agonistic antibodies can drive the activation and proliferation of effector T cells and thereby enhance a T-cell–mediated antitumor response. Systemic administration of anti-4-1BB–agonistic IgGs, although effective preclinically, has… read more here.
Keywords: specific 1bb; antitumor activity; cancer; 1bb agonistic ... See more keywords