Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection
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DOI: 10.1021/acs.jmedchem.1c00258
Abstract: Hexameric structure formation through packing of three C-terminal helices and an N-terminal trimeric coiled-coil core has been proposed as a general mechanism of class I enveloped virus entry. In this process, the C-terminal helical repeat… read more here.
Keywords: human coronavirus; trimeric coiled; hiv; infection ... See more keywords