Doping control analysis of trimetazidine in dried blood spot.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3414
Abstract: Dried blood spot (DBS) analysis has been an inherent part of sports drug testing through the technological advancements of the past decade. Trimetazidine, a non-threshold banned substance, is excreted into urine after a dose of… read more here.
Keywords: blood spot; trimetazidine; dried blood; analysis ... See more keywords
The mitochondrial metabolic reprogramming agent trimetazidine as an ‘exercise mimetic’ in cachectic C26‐bearing mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12226
Abstract: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function.… read more here.
Keywords: metabolic reprogramming; muscle; trimetazidine; reprogramming agent ... See more keywords
Early Trimetazidine Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Segment Elevation Myocardial Infarction Reduces Myocardial Infarction Size
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-021-07259-y
Abstract: Trimetazidine, a metabolic agent with anti-ischemic effects, was reported to reduce reperfusion injury in animal models. In this randomized double-blind placebo-controlled trial, we investigated the effects of trimetazidine on the reduction of infarction size in… read more here.
Keywords: myocardial infarction; group; trimetazidine; infarction ... See more keywords
Clinical Implications of Nicorandil Combined with Trimetazidine in Patients with Coronary Heart Disease: A Real-World Observational Study
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Therapy"
DOI: 10.1007/s12325-021-01987-1
Abstract: Introduction Coronary heart disease (CHD) remains the leading cause of mortality in China. The treatment strategies, especially for patients with ischemic angina pectoris, are still far from satisfactory. Hence, this study was carried out to… read more here.
Keywords: trimetazidine; study; group; rate ... See more keywords
Drug repurposing in cardiology
Sign Up to like & getrecommendations! Published in 2020 at "Netherlands Heart Journal"
DOI: 10.1007/s12471-020-01430-0
Abstract: In this month’s issue of the Netherlands Heart Journal, van de Bovenkamp et al. [1] describe their study design of the DoPING-HFpEF trial, a placebo-controlled cross-over trial that studies the effect of trimetazidine on diastolic… read more here.
Keywords: heart; cardiology; drug repurposing; trimetazidine ... See more keywords
Efficacy and safety of trimetazidine after percutaneous coronary intervention (ATPCI): a randomised, double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "The Lancet"
DOI: 10.1016/s0140-6736(20)31790-6
Abstract: BACKGROUND Angina might persist or reoccur despite successful revascularisation with percutaneous coronary intervention (PCI) and antianginal therapy. Additionally, PCI in stable patients has not been shown to improve survival compared with optimal medical therapy. Trimetazidine… read more here.
Keywords: placebo; efficacy; treatment; pci ... See more keywords
Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00648-0
Abstract: Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that may contribute to skeletal muscle injury.… read more here.
Keywords: dexamethasone induced; pyroptosis; muscle; trimetazidine ... See more keywords
Protective effect of trimetazidine in radiation-induced cardiac fibrosis in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rraa043
Abstract: Abstract Radiation-induced heart damage is a serious side effect caused by radiotherapy, especially during the treatment of cancer near the chest. Trimetazidine is effective at reducing inflammation in the heart, but how it affects radiation-induced… read more here.
Keywords: fibrosis; radiation induced; cardiac fibrosis; trimetazidine ... See more keywords
Trimetazidine affects MCU expression to restore ischemic heart function via ROS/NFκB pathway inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001434
Abstract: ABSTRACT Studies have demonstrated the roles of trimetazidine beyond being an antianginal agent in ischemic heart disease (IHD) treatment associated with mechanisms of calcium regulation. Our recent studies revealed that mitochondrial calcium uniporter (MCU, the… read more here.
Keywords: calcium; inhibition; trimetazidine; heart function ... See more keywords
Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression.
Sign Up to like & getrecommendations! Published in 2023 at "Bipolar disorders"
DOI: 10.1111/bdi.13319
Abstract: OBJECTIVES The aim of this study was to repurpose a drug for the treatment of bipolar depression. METHODS A gene expression signature representing the overall transcriptomic effects of a cocktail of drugs widely prescribed to… read more here.
Keywords: treat bipolar; bipolar depression; trimetazidine; depression ... See more keywords
Efficacy of Trimetazidine in Limiting Periprocedural Myocardial Injury in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Angiology"
DOI: 10.1177/0003319720987745
Abstract: We systematically searched the literature to assess the efficacy of trimetazidine in reducing periprocedural myocardial injury and improving postoperative left ventricular ejection fraction (LVEF) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention… read more here.
Keywords: periprocedural myocardial; analysis; myocardial injury; trimetazidine ... See more keywords