Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.09.037
Abstract: Peptide-based vaccines have the potential to overcome the limitations of classical vaccines; however, their use is hampered by a lack of carriers and adjuvants suitable for human use. In this study, an efficient self-adjuvanting peptide… read more here.
Keywords: trimethyl chitosan; delivery; antigen; group streptococcus ... See more keywords
N-trimethyl chitosan coated targeting nanoparticles improve the oral bioavailability and antioxidant activity of vitexin.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2022.119273
Abstract: Vitexin is a flavonoid which exerted many protective activities. However, the low bioavailability discounts the in vivo effects of vitexin. This study designed vitexin loaded bilayer nanoparticles by the assembly of soybean peptides and the… read more here.
Keywords: vitexin; trimethyl chitosan; bioavailability antioxidant; antioxidant activity ... See more keywords
Trimethyl chitosan postoperative irrigation solution modulates inflammatory cytokines related to adhesion formation.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2022.119380
Abstract: Lavage or irrigation has been instilled in surgical practice for wound clearance and surgical site infection prevention during and after surgery. Herein, we developed a new irrigation solution using trimethyl chitosan (TMC), a quaternized chitosan… read more here.
Keywords: irrigation; adhesion formation; irrigation solution; trimethyl chitosan ... See more keywords
Intraperitoneal immunization with Urease loaded N-trimethyl Chitosan nanoparticles elicits high protection against Brucella melitensis and Brucella abortus infections.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2018.03.004
Abstract: Brucella (B) species are brucellosis causative agents, a worldwide zoonotic illness causing Malta fever in humans and abortion in domestic animals. In this work, we evaluated the vaccine potential of Trimethyl chitosan (TMC) nanoparticles formulation… read more here.
Keywords: trimethyl chitosan; tmc urease; brucella; urease nanoparticles ... See more keywords
PEG modified trimethyl chitosan based nanoparticles for the codelivery of doxorubicin and iSur-pDNA
Sign Up to like & getrecommendations! Published in 2019 at "Materials Letters"
DOI: 10.1016/j.matlet.2018.11.161
Abstract: Abstract Doxorubicin (DOX) is one of the commonly used chemotherapeutic agents, but its clinical use is restricted by systemic toxicity and tumor multidrug resistance. To overcome these barriers, PEG modified trimethyl chitosan based nanoparticles (NPs)… read more here.
Keywords: modified trimethyl; pdna; trimethyl chitosan; chitosan based ... See more keywords
Bioconjugation of aptamer to fluorescent trimethyl chitosan nanoparticles for bacterial detection
Sign Up to like & getrecommendations! Published in 2020 at "Materials Letters"
DOI: 10.1016/j.matlet.2020.127330
Abstract: Abstract Trimethyl chitosan nanoparticles (TMC NPs), the positively charged chitosan derivative, have been used to deliver medicines to overcome the tissue barrier. Here, fluorescein-labeled TMC NPs were produced by a microemulsion method following the bioconjugation… read more here.
Keywords: bioconjugation aptamer; trimethyl chitosan; chitosan nanoparticles; tmc nps ... See more keywords
Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s165876
Abstract: The application of natural carbohydrate polysaccharides for antigen delivery and its adjuvanation potential has garnered interest in the scientific community in the recent years. These biomaterials are considered favorable candidates for adjuvant development due to… read more here.
Keywords: trimethyl chitosan; delivery; novel application; vaccine delivery ... See more keywords
Mechanism of Enhanced Oral Absorption of a Nano-Drug Delivery System Loaded with Trimethyl Chitosan Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s358832
Abstract: Introduction In the previous study, nanoparticles coated with trimethyl chitosan (TMC) derivatives (PPTT-NPs) could promote the oral bioavailability of panax notoginseng saponins (PNS). Herein, we chose PPTT-NPs as a model drug to study the property… read more here.
Keywords: tmc; pptt; mechanism; pptt nps ... See more keywords