Visible-light-mediated cleavage of polymer chains under physiological conditions via quinone photoreduction and trimethyl lock.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc07257k
Abstract: We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications. Both reactions can be carried out in water and at ambient temperature, enabling preparation of… read more here.
Keywords: trimethyl lock; cleavage polymer; photoreduction trimethyl; visible light ... See more keywords
Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01334k
Abstract: We herein report a novel chemically triggered click-to-release system, that combines the trimethyl lock (TML) lactonization with the bioorthogonal inverse electron demand Diels-Alder (IEDDA) reaction of a vinyl ether and a tetrazine. Kinetic studies were… read more here.
Keywords: system; click release; release system; tetrazine ... See more keywords