Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.13242
Abstract: Key Points Question Are trimethylamine N-oxide (TMAO), a novel plasma metabolite derived from L-carnitine and phosphatidylcholine, and related metabolites (ie, choline, betaine, carnitine, and butyrobetaine) associated with risk of death among older adults in the… read more here.
Keywords: association trimethylamine; older adults; trimethylamine oxide; risk death ... See more keywords
Trimethylamine N‐oxide and cardiovascular outcomes in patients with chronic heart failure after myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12552
Abstract: Accumulating evidence has demonstrated that intestinal microbiota‐dependent trimethylamine N‐oxide (TMAO) is involved in the pathogenesis of various cardiovascular diseases. The present study was designed to investigate the prognostic value of TMAO in patients with chronic… read more here.
Keywords: heart; heart failure; trimethylamine oxide; patients chronic ... See more keywords
Association between trimethylamine N‐oxide and prognosis of patients with acute myocardial infarction and heart failure
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14009
Abstract: This study aimed to investigate the association between trimethylamine N‐oxide (TMAO) and the prognosis and association between high‐sensitivity C‐reactive protein (hsCRP) and TMAO‐associated cardiovascular risk in patients with acute myocardial infarction (AMI) complicated by heart… read more here.
Keywords: trimethylamine oxide; heart failure; association; association trimethylamine ... See more keywords
The role of trimethylamine-N-Oxide in the development of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30646
Abstract: Alzheimer's disease is associated with multiple risk factors and is the most common type of dementia. Trimethylamine-N-oxide (TMAO), a gut microbiota metabolite derived from dietary choline and carnitine, has recently been identified as a potential… read more here.
Keywords: alzheimer disease; role trimethylamine; trimethylamine oxide; disease ... See more keywords
Distinct influence of trimethylamine N-oxide and high hydrostatic pressure on community structure and culturable deep-sea bacteria
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oceanology and Limnology"
DOI: 10.1007/s00343-019-9076-y
Abstract: Trimethylamine N-oxide (TMAO) is one of the most important nutrients for bacteria in the deep-sea environment and is capable of improving pressure tolerance of certain bacterial strains. To assess the impact of TMAO on marine… read more here.
Keywords: deep sea; community; trimethylamine oxide; bacterial community ... See more keywords
Circulating trimethylamine N-oxide levels following fish or seafood consumption
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Nutrition"
DOI: 10.1007/s00394-022-02803-4
Abstract: Some species of fish and seafood are high in trimethylamine N-oxide (TMAO), which accumulates in muscle where it protects against pressure and cold. Trimethylamine (TMA), the metabolic precursor to TMAO, is formed in fish during… read more here.
Keywords: tmao levels; fish seafood; tmao; seafood consumption ... See more keywords
What is the hydrophobic interaction contribution to the stabilization of micro-hydrated complexes of trimethylamine oxide (TMAO)? A joint DFT-D, QTAIM, and MESP study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4217-y
Abstract: Micro-hydrated trimethylamine oxide (TMAO) has been investigated using a range-separated-hybrid functional including empirical dispersion correction. Electrophilic and nucleophilic sites on TMAO and water clusters have been identified using the molecular electrostatic potential (MESP). The nature… read more here.
Keywords: micro hydrated; water; tmao; hydrated complexes ... See more keywords
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-021-09656-z
Abstract: Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or L-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver. As the function of gut microbiota and… read more here.
Keywords: trimethylamine oxide; tmao; tma tmao; cardiovascular diseases ... See more keywords
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.1016/j.cmet.2022.02.010
Abstract: Immunotherapy has achieved limited success in patients with triple-negative breast cancer (TNBC), an aggressive disease with a poor prognosis. Commensal microbiota have been proven to colonize the mammary gland, but whether and how they modulate… read more here.
Keywords: triple negative; metabolite trimethylamine; negative breast; breast cancer ... See more keywords
Increased plasma trimethylamine-N-oxide is associated with incident atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.04.128
Abstract: BACKGROUND Plasma trimethylamine-N-oxide (TMAO) is associated with cardiovascular disease; however specific relationships with cardiac arrhythmias are unknown. We evaluated the association between plasma TMAO and incident atrial fibrillation (AF). METHODS Risk associations were explored among… read more here.
Keywords: atrial fibrillation; risk; tmao; incident atrial ... See more keywords
GW28-e0577 Trimethylamine-N-oxide induces the osteogenic responses of human aortic valve interstitisl cells through the endoplasmic reticulum-mitochondrial stress pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.061
Abstract: The recent studies show that the choline-derived metabolite trimethylamine N-oxide (TMAO) levels are associated with the development of cardiovascular diseases. TMAO causes cell inflammation and endoplasmic reticulum stress. Inflammatory responses and endoplasmic reticulum stress are involved… read more here.
Keywords: endoplasmic reticulum; reticulum; trimethylamine oxide; stress ... See more keywords